Relations between early maternal sensitivity and toddler self-regulation: Exploring variation by oxytocin and dopamine D2 receptor genes.

Autor: Augustine ME; The University of North Carolina at Greensboro, Greensboro, North Carolina.; The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Leerkes EM; The University of North Carolina at Greensboro, Greensboro, North Carolina., Smolen A; The University of Colorado, Denver, Colorado., Calkins SD; The University of North Carolina at Greensboro, Greensboro, North Carolina.
Jazyk: angličtina
Zdroj: Developmental psychobiology [Dev Psychobiol] 2018 Nov; Vol. 60 (7), pp. 789-804. Date of Electronic Publication: 2018 Jun 13.
DOI: 10.1002/dev.21745
Abstrakt: Gene-by-environment interactions between maternal sensitivity during infancy and child oxytocin receptor gene (OXTR rs53576) and D2 dopamine receptor gene (DRD2 TaqIA, rs1822497) genotypes were explored as predictors of toddlers' well-regulated behavioral and physiological responses to maternal compliance demands. Maternal sensitivity was assessed across a range of mother-child interactions when children were 6 months and 1 year of age (N = 186), and toddler self-regulatory responses were assessed through compliance and vagal withdrawal during a toy clean-up task when children were 2 years of age. Sensitivity-by-OXTR interactions suggested two diathesis-stress patterns, predicting compliance for the GG genotype group, and predicting physiological regulation for the AA/AG genotype group. A main effect for DRD2 genotype indicated that children with an A1 allele displayed less-compliant behavior in toddlerhood. These results suggest that genetic differences may contribute to variation both in risk for self-regulatory difficulties, and in relations between maternal sensitivity and children's responses to compliance demands at different levels of analysis.
(© 2018 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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