| Autor: |
Mason RT, Coghlan JP, Congiu M, Denton DA, Fei DT, Whitworth JA, Scoggins BA |
| Jazyk: |
angličtina |
| Zdroj: |
Prostaglandins, leukotrienes, and medicine [Prostaglandins Leukot Med] 1985 May; Vol. 18 (2), pp. 261-9. |
| DOI: |
10.1016/0262-1746(85)90026-5 |
| Abstrakt: |
The present experiments examine the hemodynamic effects of an intravenous infusion of prostacyclin on the development of ACTH-induced hypertension in conscious sheep. Prostacyclin was infused at either 0.01 microgram/kg min-1 for 9 days or 0.25 microgram/kg min-1 for 4 days. At 0.01 microgram/kg min-1 prostacyclin had no effect on blood pressure in normotensive sheep or on the development of ACTH hypertension. Infusion at 0.25 microgram/kg min-1 increased heart rate, cardiac output and plasma renin concentration and decreased stroke volume and peripheral resistance in normotensive sheep. Despite these effects it did not prevent development of ACTH-induced hypertension. It is unlikely on the basis of these results that glucocorticoid-induced inhibition of vasodepressor prostacyclin and resulting increase in pressor responsiveness to circulating agonists is the primary cause of ACTH induced hypertension in sheep. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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