The effect of lifestyle on late-life cognitive change under different socioeconomic status.

Autor: Weng PH; Department of Family Medicine, Taiwan Adventist Hospital, Taipei, Taiwan.; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan., Chen JH; Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan., Chiou JM; Institute of Statistical Science, Academia Sinica, Taipei, Taiwan., Tu YK; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan., Chen TF; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Chiu MJ; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Tang SC; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Yeh SJ; Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan., Chen YC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.; Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.; Research Center for Genes, Environment and Human Health, College of Public Health, National Taiwan University, Taipei, Taiwan.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2018 Jun 13; Vol. 13 (6), pp. e0197676. Date of Electronic Publication: 2018 Jun 13 (Print Publication: 2018).
DOI: 10.1371/journal.pone.0197676
Abstrakt: This study aimed to identify lifestyle factors associated with cognitive change and to explore whether the effect of lifestyle varies by socioeconomic status (SES). Participants aged 65 years and older were recruited from elderly health checkup programs from 2011 to 2013 in Taiwan. Neuropsychological tests, including tests of global cognition, logical memory, executive function, verbal fluency and attention, were administered at baseline (N = 603) and 2 years later (N = 509). After literature review, 9 lifestyle factors and 3 SES indicators were chosen and their effects on cognitive change were evaluated using linear regression adjusting for age, sex, education, APOE ε4 status, and baseline cognitive score. Five lifestyle factors (high vegetable and fish intake, regular exercise, not smoking, and light to moderate alcohol consumption) and 3 SES indicators [annual household income (> 33,333 USD vs. less), occupational complexity (high vs. low mental demanding job), and years of education (> 12 years vs. less)] were found to be protective against cognitive decline (P < 0.1 in any cognitive domains, ß ranging from 0.06 to 0.38). After further adjusting for all the lifestyle and SES factors, fish intake, higher income and occupational complexity remained protective. Significant interactions were found between a healthful lifestyle (defined as having ≥ 3 healthful lifestyle factors) and income on changes of global cognition and verbal fluency (Pinteraction = 0.02 and 0.04). The protective effect of a healthful lifestyle was observed only among participants with lower income in global cognition and logical memory [ß = 0.17, 95% confidence interval (CI) = 0.07-0.26; ß = 0.30, 95% CI = 0.14-0.46]. To the best of our knowledge, this study for the first time explored how the interactions of lifestyle and SES affect cognitive change. Our findings will aid in developing dementia prevention programs and reduce health inequalities.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje