Hippocampal Subfield Volumes in Patients With First-Episode Psychosis.

Autor:	Baglivo V; Unit of Psychiatry, Department of Medicine, University of Udine, Udine, Italy., Cao B; UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX., Mwangi B; UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX., Bellani M; UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy.; InterUniversity Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy., Perlini C; InterUniversity Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy.; Department of Public Health and Community Medicine, Section of Clinical Psychology, University of Verona, Verona, Italy., Lasalvia A; UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy., Dusi N; UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy.; InterUniversity Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy., Bonetto C; Section of Psychiatry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy., Cristofalo D; Section of Psychiatry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy., Alessandrini F; Neuroradiology Department, Azienda Ospedaliera Universitaria, Verona, Italy., Zoccatelli G; Neuroradiology Department, Azienda Ospedaliera Universitaria, Verona, Italy., Ciceri E; Neuroradiology Department, Azienda Ospedaliera Universitaria, Verona, Italy., Dario L; Department of Psychiatry, CSM AULSS 21 Legnago, Verona, Italy., Enrico C; Department of Mental Health, Hospital of Montecchio Maggiore, Vicenza, Italy., Francesca P; Department of Mental Health, Azienda ULSS Bologna, Bologna, Italy., Mazzi F; Department of Mental Health, Modena, Italy., Paolo S; Department of Neuroscience, University of Padova, Padova, Italy., Balestrieri M; Unit of Psychiatry, Department of Medicine, University of Udine, Udine, Italy., Soares JC; UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX., Ruggeri M; UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy.; Section of Psychiatry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy., Brambilla P; UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.; Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
Jazyk:	angličtina
Zdroj:	Schizophrenia bulletin [Schizophr Bull] 2018 Apr 06; Vol. 44 (3), pp. 552-559.
DOI:	10.1093/schbul/sbx108
Abstrakt:	Background: Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis. Aim: The aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP). Methods: Magnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates. Results: We found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS). Conclusion: We report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset.
Databáze:	MEDLINE
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