| Autor: |
Joshi MS, Tandale BV, Gore MM, Bhalla S, Gurav YK, Sapkal GN, Kushwaha KP, Mishra AC, Chitambar SD |
| Jazyk: |
angličtina |
| Zdroj: |
Acta virologica [Acta Virol] 2018; Vol. 62 (2), pp. 208-213. |
| DOI: |
10.4149/av_2018_215 |
| Abstrakt: |
The etiological agent remained unidentified in a large number of patients hospitalized for acute encephalitis syndrome (AES) in 2008-2009 in Uttar Pradesh and Bihar, north India. All patients were found to present with fever and altered sensorium, while 28%, 19% and 13% showed hepatomegaly, splenomegaly and meningeal signs, respectively. Involvement mostly of children with abnormal hepatic features prompted us to undertake an exploratory study on viral hepatitis A to determine its association, if any, with hepatic derangements. AES patients (n = 2515) and healthy children (n = 167) were investigated for the presence of serum anti-hepatitis A virus (anti-HAV) IgM and anti-Japanese encephalitis (anti-JE) virus IgM by ELISA. Cerebrospinal fluids (CSFs, n = 595) and rectal swabs (n = 182) were examined for anti-HAV IgM and/or HAV RNA. Anti-HAV IgM was detected in the sera of 14.6% patients as against 6.6% of healthy children (p = 0.0042). Anti-JE virus IgM positivity was Keywords: acute encephalitis syndrome; cerebrospinal fluid; hepatitis A virus; anti-HAV IgM; non-Japanese encephalitis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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