Role of human Cytomegalovirus in the etiology of nasopharyngeal carcinoma.
| Autor: | Ahmed HG; Molecular Diagnostics and Personalized Therapeutics Unit, University of Hail; Department of Pathology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia; Department of Histopathology and Cytology, FMLS, University of Khartoum, Khartoum, Sudan., Suliman RSA; Department of Histopathology and Cytology, Faculty of Medical Laboratory Science, Sudan University for Science and Technology, Khartoum, Sudan., Ashankyty IM; Molecular Diagnostics and Personalized Therapeutics Unit, University of Hail; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Kingdom of Saudi Arabia., Albieh ZA; Department of Pathology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia., Warille AA; Department of Anatomy and Histology, College of Medicine, University of Hail, Hail, Kingdom of Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cancer research and therapeutics [J Cancer Res Ther] 2018 Apr-Jun; Vol. 14 (3), pp. 583-586. |
| DOI: | 10.4103/0973-1482.176175 |
| Abstrakt: | Objective: The purpose of this study was to identify human Cytomegalovirus (HCMV) in tissue blocks obtained from patients with nasopharyngeal carcinoma (NPC). Materials and Methods: Formalin-fixed paraffin wax processed NPC tissue were obtained from 150 tissue blocks and retrospectively investigated for the presence of HCMV using polymerase chain reaction. Results: Of the 150 NPC tissue specimens, HCMV was identified in 53/150 (35.3%) of the samples. Out of the 53 samples infected with HCMV, 33/97 (34%) were among males and 20/53 (37.7%) were among females. Of the 53 positive samples, 36/53 (68%) were found to harbor Epstein-Barr virus (EBV). Conclusion: The present study has shown a relatively considerable association between HCMV and NPC. The great majority of samples sheltering HCMV were also found to hide EBV, which proposes the potentiality of EBV over HCMV. Competing Interests: There are no conflicts of interest |
| Databáze: | MEDLINE |
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