| Autor: |
Kutyrev VV; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia., Eroshenko GA; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia., Motin VL; Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States.; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States., Nosov NY; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia., Krasnov JM; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia., Kukleva LM; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia., Nikiforov KA; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia., Al'khova ZV; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia., Oglodin EG; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia., Guseva NP; Russian Research Anti-Plague Institute 'Microbe', Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare, Saratov, Russia. |
| Abstrakt: |
The established phylogeny of the etiological agent of plague, Yersinia pestis , is not perfect, as it does not take into account the strains from numerous natural foci of Commonwealth of Independent States (CIS). We have carried out PCR and SNP typing of 359 strains and whole genome sequencing of 51 strains from these plague foci and determined the phylogenetic diversity of the strains circulating here. They belong to 0.ANT3, 0.ANT5, 2.ANT3, 4.ANT branches of antique biovar, 2.MED0, 2.MED1 branches of medieval biovar and to 0.PE2, 0.PE4a. 0.PE4h, 0.PE4t branches. Based on the studies of 178 strains from 23 plague foci of CIS countries, it was determined that the population structure of 2.MED strains is subdivided into Caucasian-Caspian and Central Asian-Chinese branches. In Central-Caucasian high-mountain plague foci in the Russian Federation (RF) the most deeply diverged branch of medieval biovar, 2.MED0, has been found. With the data obtained, the current population structure of Y. pestis species has been refined. New subspecies classification is developed, comprising seven subspecies: pestis, caucasica (0.PE2), angolica (0.PE3), central asiatica (0.PE4), tibetica (0.PE7), ulegeica (0.PE5), and qinghaica (0.PE10). |
