| Autor: |
Jones CR, McCullouch J, Butters L, Hamilton CA, Rubin PC, Reid JL |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of obstetrics and gynaecology [Br J Obstet Gynaecol] 1985 Jun; Vol. 92 (6), pp. 593-9. |
| DOI: |
10.1111/j.1471-0528.1985.tb01397.x |
| Abstrakt: |
Catecholamines were measured in maternal venous, and mixed umbilical cord blood. Maternal catecholamines were significantly (P less than 0.01) reduced by epidural analgesia with a 36% reduction in noradrenaline and a 33% reduction in adrenaline. Fetal catecholamines were elevated at birth with a 3-8 fold increase in noradrenaline but not adrenaline during spontaneous vaginal delivery. The lowest fetal catecholamines were obtained in the group delivered under epidural analgesia; lower plasma catecholamines were not associated with adverse respiratory effects. Fetal platelets showed impaired alpha 2-adrenoceptor function with absent aggregatory responses to adrenaline in vitro. The defect in platelet function was unlikely to be related to changes in the number of fetal platelet alpha-receptors or to changes in receptor affinity for adrenaline, as fetal platelets failed to aggregate to adrenaline from deliveries with high and low cord blood catecholamines. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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