The real-world outcomes of treating Polycythemia Vera: Physician adherence to treatment guidelines.

Autor: Jackson Chornenki NL; McMaster University, Hamilton, Ontario, Canada. Electronic address: nicholas.jacksonchornenki@medportal.ca., Chai-Adisaksopha C; McMaster University, Hamilton, Ontario, Canada., Leong DP; McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada., Siegal DM; McMaster University, Hamilton, Ontario, Canada; Population Health Research Institute, Hamilton, Ontario, Canada., Hillis CM; McMaster University, Hamilton, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Jazyk: angličtina
Zdroj: Leukemia research [Leuk Res] 2018 Jul; Vol. 70, pp. 62-66. Date of Electronic Publication: 2018 Jun 04.
DOI: 10.1016/j.leukres.2018.06.001
Abstrakt: Therapy in Polycythemia Vera (PV), a myeloproliferative neoplasm, focuses on reducing cardiovascular (CV) risk without increasing bleeding or hematological progression. However, the real-world practice of treating PV in North America is understudied. We performed a retrospective cohort study of newly diagnosed PV (JAK2V617F mutation positive) patients in Hamilton, Canada to fill this knowledge gap. Out of 108 patients included, (n = 45, 41.7%) patients did not receive therapy consistent with contemporary treatment guidelines. Multivariable analysis showed increased white blood cell count at diagnosis (HR, 1.09; 95% CI, 1.04-1.14; p < 0.001), older age (HR, 1.15; 95% CI, 1.07-1.23; p < 0.001) and diabetic history (HR, 3.71; 95% CI, 1.27-10.78; p = 0.012) associated with greater mortality. Not receiving pharmacological treatment according to guidelines was also independently associated with increased mortality (HR, 3.12; 95% CI, 1.13-8.65; p = 0.029).
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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