Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta.

Autor: Neradugomma NK; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States. Electronic address: naveennk@uw.edu., Drafton K; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States., O'Day DR; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, United States., Liao MZ; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States., Han LW; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States., Glass IA; Department of Pediatrics, School of Medicine, University of Washington, Seattle, WA 98195, United States., Mao Q; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, United States. Electronic address: qmao@uw.edu.
Jazyk: angličtina
Zdroj: Placenta [Placenta] 2018 Jun; Vol. 66, pp. 36-39. Date of Electronic Publication: 2018 May 09.
DOI: 10.1016/j.placenta.2018.05.002
Abstrakt: Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express CNR1 and CNR2 and can respond to cannabinoid signaling. In this study, we show that marijuana use significantly increases mRNA or protein expression of CNR1 and CNR2 in human endometrium from the first and early second trimester pregnancies, with minor effects on placental expression of CNRs.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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