Relationship of In Vivo MR Parameters to Histopathological and Molecular Characteristics of Newly Diagnosed, Nonenhancing Lower-Grade Gliomas.

Autor:	Luks TL; Department of Radiology and Biomedical Imaging, University of California San Francisco. Electronic address: Tracy.Luks@ucsf.edu., McKnight TR; Department of Radiology and Biomedical Imaging, University of California San Francisco., Jalbert LE; Department of Radiology and Biomedical Imaging, University of California San Francisco., Williams A; Department of Radiology and Biomedical Imaging, University of California San Francisco., Neill E; Department of Radiology and Biomedical Imaging, University of California San Francisco., Lobo KA; Department of Radiology and Biomedical Imaging, University of California San Francisco., Persson AI; Department of Neurology, University of California San Francisco., Perry A; Department of Neurology, University of California San Francisco., Phillips JJ; Department of Pathology, University of California San Francisco; Department of Neurological Surgery, University of California San Francisco., Molinaro AM; Department of Neurological Surgery, University of California San Francisco; Department of Epidemiology and Biostatistics, University of California San Francisco., Chang SM; Department of Neurological Surgery, University of California San Francisco., Nelson SJ; Department of Radiology and Biomedical Imaging, University of California San Francisco.
Jazyk:	angličtina
Zdroj:	Translational oncology [Transl Oncol] 2018 Aug; Vol. 11 (4), pp. 941-949. Date of Electronic Publication: 2018 Jun 18.
DOI:	10.1016/j.tranon.2018.05.005
Abstrakt:	The goal of this research was to elucidate the relationship between WHO 2016 molecular classifications of newly diagnosed, nonenhancing lower grade gliomas (LrGG), tissue sample histopathology, and magnetic resonance (MR) parameters derived from diffusion, perfusion, and 1 H spectroscopic imaging from the tissue sample locations and the entire tumor. A total of 135 patients were scanned prior to initial surgery, with tumor cellularity scores obtained from 88 image-guided tissue samples. MR parameters were obtained from corresponding sample locations, and histograms of normalized MR parameters within the T2 fluid-attenuated inversion recovery lesion were analyzed in order to evaluate differences between subgroups. For tissue samples, higher tumor scores were related to increased normalized apparent diffusion coefficient (nADC), lower fractional anisotropy (nFA), lower cerebral blood volume (nCBV), higher choline (nCho), and lower N-acetylaspartate (nNAA). Within the T2 lesion, higher tumor grade was associated with higher nADC, lower nFA, and higher Cho to NAA index. Pathological analysis confirmed that diffusion and metabolic parameters increased and perfusion decreased with tumor cellularity. This information can be used to select targets for tissue sampling and to aid in making decisions about treating residual disease. (Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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