"Frontal lobe syndrome"? Subtypes of acquired personality disturbances in patients with focal brain damage.

Autor: Barrash J; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA. Electronic address: joseph-barrash@uiowa.edu., Stuss DT; Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Rotman Research Institute of Baycrest, Toronto, Ontario, Canada., Aksan N; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Anderson SW; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Jones RD; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Manzel K; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Tranel D; Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA, USA; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.
Jazyk: angličtina
Zdroj: Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2018 Sep; Vol. 106, pp. 65-80. Date of Electronic Publication: 2018 May 16.
DOI: 10.1016/j.cortex.2018.05.007
Abstrakt: Conceptualizations of the nature of acquired personality disturbances after brain damage, especially to prefrontal cortex, have progressed from clinical observations of a large, disparate set of disturbances to theories concerning neuroanatomically-based subgroups with prefrontal damage. However, hypothesized subtypes have not yet been studied systematically. Based on our previous investigations of acquired personality disturbances, we hypothesized five subtypes of acquired personality disturbances: Executive Disturbances, Disturbed Social Behavior, Emotional Dysregulation, Hypo-emotionality/De-Energization, and Distress, as well as an undisturbed group. Subtypes were investigated in 194 adults with chronic, stable, focal lesions located in various aspects of prefrontal lobes and elsewhere in the brain, using two different cluster analysis techniques applied to ratings on the Iowa Scales of Personality Change. One technique was a hypothesis-driven approach; the other was a set of strictly empirical analyses to assess the robustness of clusters found in the first analysis. The hypothesis-driven analysis largely supported the hypothesized set of subtypes. However, in contrast to the hypothesis, it suggested that disturbed social behavior and emotional dysregulation are not two distinct subtypes, but two aspects of one multifaceted type of disturbance. Additionally, the so-labeled "executive disturbances" group also showed disturbances in other domains. Results from the second (empirical) set of cluster analyses were consistent with findings from the hypothesis-driven cluster analysis. Overall, findings across the two cluster analyses indicated four subtypes of acquired personality disturbances: (1) executive disturbances in association with generalized disturbance, (2) dysregulation of emotions and behavior, (3) hypo-emotionality and de-energization, and (4) distress/anxiety. These findings show strong correspondence with subtypes suggested by prominent models of prefrontal systems based on neuroanatomically-defined circuits. Clarification of distinctive subtypes of acquired personality disturbances is a step toward enhancing our ability to tailor rehabilitative interventions for patients with prefrontal brain injuries.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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