| Autor: |
Kokanova-Nedialkova Z; a Faculty of Pharmacy, Department of Pharmacognosy , Medical University of Sofia , Sofia , Bulgaria., Nedialkov PT; a Faculty of Pharmacy, Department of Pharmacognosy , Medical University of Sofia , Sofia , Bulgaria., Momekov G; b Faculty of Pharmacy, Department of Pharmacology, Pharmacotherapy and Toxicology , Medical University of Sofia , Sofia , Bulgaria. |
| Jazyk: |
angličtina |
| Zdroj: |
Natural product research [Nat Prod Res] 2019 Jul; Vol. 33 (14), pp. 2024-2031. Date of Electronic Publication: 2018 Jun 08. |
| DOI: |
10.1080/14786419.2018.1483928 |
| Abstrakt: |
Two new glycosides of phytolaccagenin and 2 β -hydroxyoleanoic acid, namely bonushenricoside A ( 3 ) and bonushenricoside B ( 5 ) together with four known saponins, respectively compounds 3-O-L- α -arabinopyranosyl-bayogenin-28-O- β -glucopyranosyl ester ( 1 ), 3-O- β -glucuronopyranosyl-2 β -hydroxygypsogenin-28-O- β -glucopyranosyl ester ( 2 ), 3-O- β -glucuronopyranosyl-bayogenin-28-O- β -glucopyranosyl ester ( 4 ) and 3-O- β -glucuronopyranosyl-medicagenic acid-28- β -xylopyranosyl(1→4)- α -rhamnopyranosyl(1→2)- α -arabinopyranosyl ester ( 6 ) were isolated from the roots of Chenopodium bonus - henricus L. The structures of the compounds were determined by means of spectroscopic methods (1D and 2D NMR, IR and HRMS). The MeOH extract and compounds were tested for cytotoxic activity on five leukemic cell lines (HL-60, SKW-3, Jurkat E6-1, BV-173 and K-562). In addition, the ability of metanolic extract and saponins to modulate the interleukin-2 production in PHA/PMA stimulated Jurkat E6-1 cells was investigated as well. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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