| Autor: |
Young JF, Hockmeyer WT, Gross M, Ballou WR, Wirtz RA, Trosper JH, Beaudoin RL, Hollingdale MR, Miller LH, Diggs CL, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1985 May 24; Vol. 228 (4702), pp. 958-62. |
| DOI: |
10.1126/science.2988125 |
| Abstrakt: |
The circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum may be the most promising target for the development of a malaria vaccine. In this study, proteins composed of 16, 32, or 48 tandem copies of a tetrapeptide repeating sequence found in the CS protein were efficiently expressed in the bacterium Escherichia coli. When injected into mice, these recombinant products resulted in the production of high titers of antibodies that reacted with the authentic CS protein on live sporozoites and blocked sporozoite invasion of human hepatoma cells in vitro. These CS protein derivatives are therefore candidates for a human malaria vaccine. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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