Pure Polyphenols Applications for Cardiac Health and Disease.

Autor:	Santos CN; iBET, Instituto de Biologia Experimental e Tecnologica, Apartado 12, 2780-901 Oeiras, Portugal.; nstituto de Tecnologia Quimica e Biologica Antonio Xavier, Universidade Nova de Lisboa, Av. da Republica, 2780-157 Oeiras, Portugal., Gomes A; iBET, Instituto de Biologia Experimental e Tecnologica, Apartado 12, 2780-901 Oeiras, Portugal.; nstituto de Tecnologia Quimica e Biologica Antonio Xavier, Universidade Nova de Lisboa, Av. da Republica, 2780-157 Oeiras, Portugal., Oudot C; INSERM UMR-S 1180- LabEx LERMIT, Universite Paris-Sud, Universite Paris-Saclay, 5 rue Jean-Baptiste Clement 92296 Chatenay Malabry, France., Dias-Pedroso D; CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Campo dos Martires da Patria, 130, 1169-056, Lisboa, Portugal., Rodriguez-Mateos A; Division of Diabetes and Nutritional Sciences, Faculty of Life Sciences and Medicine, King`s College London, 150 Stamford Street, SE1 9NH, London, United Kingdom., Vieira HLA; CEDOC, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade Nova de Lisboa, Campo dos Martires da Patria, 130, 1169-056, Lisboa, Portugal., Brenner C; INSERM UMR-S 1180- LabEx LERMIT, Universite Paris-Sud, Universite Paris-Saclay, 5 rue Jean-Baptiste Clement 92296 Chatenay Malabry, France.
Jazyk:	angličtina
Zdroj:	Current pharmaceutical design [Curr Pharm Des] 2018; Vol. 24 (19), pp. 2137-2156.
DOI:	10.2174/1381612824666180608102344
Abstrakt:	Polyphenols are natural compounds present in fruits and vegetables that can exert beneficial effects on human health and notably, on the cardiovascular system. Some of these compounds showed significant protective activities toward atherosclerosis, hypertension, myocardial infarction, anthracyclin-induced cardiomyopathy, angiogenesis as well as heart failure. Polyphenols can act through systemic effects as well as through modulation of signaling pathways such as redox signaling, inflammation, autophagy and cell death in the heart and vessels. These effects can be mediated by changes in expression level and by post-translational modifications of proteins (e.g. Stat1, CaMKII, Sirtuins, BCL-2 family members, PDEs, TRF2, eNOS and SOD). This non-comprehensive short review aims to summarize recent knowledge on the main pharmacological effects and mechanisms of cardioprotection of pure polyphenols, using different approaches such as cell culture, animal models and human studies. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu