Epidemiology of pyoderma gangrenosum: Results from an Italian prospective multicentre study.

Autor: Monari P; Department of Dermatology, ASST degli Spedali Civili, Spedali Civili di Brescia, Brescia, Italy., Moro R; Department of Dermatology, ASST degli Spedali Civili, Spedali Civili di Brescia, Brescia, Italy., Motolese A; Department of Dermatology, ASST dei Sette Laghi, Ospedale di Circolo e Fondazione Macchi di Varese, Varese, Italy., Misciali C; Division of Dermatology, Department of Specialized, Experimental, and Diagnostic Medicine, University of Bologna, Azienda Ospedaliera Sant'Orsola-Malpighi, Bologna, Italy., Baraldi C; Division of Dermatology, Department of Specialized, Experimental, and Diagnostic Medicine, University of Bologna, Azienda Ospedaliera Sant'Orsola-Malpighi, Bologna, Italy., Fanti PA; Division of Dermatology, Department of Specialized, Experimental, and Diagnostic Medicine, University of Bologna, Azienda Ospedaliera Sant'Orsola-Malpighi, Bologna, Italy., Caccavale S; Department of Dermatology, Second University of Naples, Naples, Italy., Puviani M; Department of Dermatology and Dermatologic Surgery, Ospedale di Sassuolo, Italy., Olezzi D; Department of Dermatology and Dermatologic Surgery, Ospedale di Sassuolo, Italy., Zampieri P; Department of Dermatology, Azienda Sanitaria dell'Alto Adige-Comprensorio Sanitario di Merano, Ospedale 'F. Tappeiner', Merano, Italy., Trevisan G; Department of Dermatology, University of Trieste, Trieste, Italy., Nan K; Department of Dermatology, University of Trieste, Trieste, Italy., Fiorentini C; Department of Dermatology, Policlinico di Modena, Modena, Italy., Pellacani G; Department of Dermatology, University of Modena and Reggio-Emilia, Modena, Italy., Gualdi G; Department of Dermatology, ASST degli Spedali Civili, Spedali Civili di Brescia, Brescia, Italy.
Jazyk: angličtina
Zdroj: International wound journal [Int Wound J] 2018 Dec; Vol. 15 (6), pp. 875-879. Date of Electronic Publication: 2018 Jun 06.
DOI: 10.1111/iwj.12939
Abstrakt: Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterised by painful, necrotic ulcerations. PG is described as a rare disease: the world-wide incidence is estimated to be around 3 to 10 cases per million population per year. These estimations are based mostly on case reports and retrospective case series; there are no prospective, multicentre studies on the matter. The apparent rarity of PG is in contrast with our clinical perception as dermatologists: in our opinion, PG is not so uncommon. Therefore, we decide to investigate the epidemiology of PG in the Italian population and confirm our clinical suspicions that it is not an orphan disease. We enrolled all patients diagnosed with PG in 8 Italian Dermatological Departments from 1st October 2014 to 1st November 2015, and we recorded their features. Our data, collected from 64 patients, are in accordance with those of the published literature regarding the epidemiology and features of PG. In an Italian population of roughly 8 million inhabitants of 7 provinces, we found an incidence of 5.17 new cases per million population per year. Unlike our predictions before the study, we confirmed the world-wide incidence of PG. To our knowledge, this is the first observational, multicentre study on PG. We hope that it provides a stimulus for further researches on PG and for the creation of an Italian register.
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Databáze: MEDLINE
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