Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease.

Autor: Baglietto-Vargas D; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California.; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., Prieto GA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Limon A; Department of Psychiatry and Human Behavior, University of California, Irvine, California., Forner S; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Rodriguez-Ortiz CJ; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Division of Occupational and Environmental Medicine, Department of Medicine, Center for Occupational and Environmental Health (COEH), University of California, Irvine, California., Ikemura K; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Ager RR; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Medeiros R; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Qld, Australia., Trujillo-Estrada L; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., Martini AC; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California., Kitazawa M; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Division of Occupational and Environmental Medicine, Department of Medicine, Center for Occupational and Environmental Health (COEH), University of California, Irvine, California., Davila JC; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., Cotman CW; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California.; Department of Neurology, University of California, Irvine, California., Gutierrez A; Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain., LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.; Department of Neurobiology and Behavior, University of California, Irvine, California.
Jazyk: angličtina
Zdroj: Aging cell [Aging Cell] 2018 Aug; Vol. 17 (4), pp. e12791. Date of Electronic Publication: 2018 Jun 06.
DOI: 10.1111/acel.12791
Abstrakt: Alzheimer's disease (AD) is a devastating neurodegenerative disorder that impairs memory and causes cognitive and psychiatric deficits. New evidences indicate that AD is conceptualized as a disease of synaptic failure, although the molecular and cellular mechanisms underlying these defects remain to be elucidated. Determining the timing and nature of the early synaptic deficits is critical for understanding the progression of the disease and for identifying effective targets for therapeutic intervention. Using single-synapse functional and morphological analyses, we find that AMPA signaling, which mediates fast glutamatergic synaptic transmission in the central nervous system (CNS), is compromised early in the disease course in an AD mouse model. The decline in AMPA signaling is associated with changes in actin cytoskeleton integrity, which alters the number and the structure of dendritic spines. AMPA dysfunction and spine alteration correlate with the presence of soluble but not insoluble Aβ and tau species. In particular, we demonstrate that these synaptic impairments can be mitigated by Aβ immunotherapy. Together, our data suggest that alterations in AMPA signaling and cytoskeletal processes occur early in AD. Most important, these deficits are prevented by Aβ immunotherapy, suggesting that existing therapies, if administered earlier, could confer functional benefits.
(© 2018 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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