Pattern of presentation of Graves' disease and response to radioiodine therapy in South African men.

Autor: Onimode YA; Nuclear Medicine Unit, Department of Radiation Oncology, College of Medicine, Faculty of Clinical Sciences, University of Ibadan, Oyo State, Nigeria.; Nuclear Medicine Centre, University College Hospital, Ibadan, Oyo State, Nigeria., Dairo DM; Department of Epidemiology & Medical Statistics, College of Medicine, Faculty of Public Health, University of Ibadan, Oyo State, Nigeria.; Department of Epidemiology & Medical Statistics, University College Hospital, Ibadan, Oyo State, Nigeria., Ellmann A; Division of Nuclear Medicine, Department of Medical Imaging & Clinical Oncology, Tygerberg Hospital, Western Cape Province, South Africa.; Faculty of Medicine and Health Sciences, Stellenbosch University, Western Cape Province, South Africa.
Jazyk: angličtina
Zdroj: The Pan African medical journal [Pan Afr Med J] 2018 Jan 18; Vol. 29, pp. 48. Date of Electronic Publication: 2018 Jan 18 (Print Publication: 2018).
DOI: 10.11604/pamj.2018.29.48.13655
Abstrakt: Introduction: Typically hyperthyroidism has been more often associated with the female gender. There is a large female predilection (male:female sex ratio up to 1:10), with little documentation in the literature about wholly male hyperthyroid populations. A male incidence of 0.7 per 100, 000 has been reported for South African men while the women have a relatively higher rate of 0.02. There is no documented evidence between male and female genders in response to treatment of PH with radioactive iodine (RAI), although operational evidence suggests that hyperthyroidism in males is less amenable to RAI treatment (RAIT) than females. This study therefore proposed to evaluate male hyperthyroid patients with Graves' disease (GD) treated at our facility, for factors affecting outcome of RAIT.
Methods: This is a retrospective analysis of records of hyperthyroid patients who were treated with RAI over a 19-year period at a university teaching hospital, in the Western Cape of South Africa.
Results: The overall cure rate was 76.4% for these male patients. Cure was observed as euthyroidism in 31 patients (15.3%) and hypothyroidism in 129 (63.5%). Age, thyroid uptake, severity of hyperthyroidism, previous antithyroid drug (ATD) usage, administered quantity of RAI, ethnicity and patients' pulse at presentation were not significant in influencing outcome.
Conclusion: Factors which have been evaluated as affecting outcome of RAIT were unimportant in these patients. Despite the mainly hyperthyroid presentation of the patients, RAIT was so effective that the main type of cure after therapy was hypothyroidism.
Databáze: MEDLINE
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