JAK-STAT signaling pathway inhibition: a role for treatment of discoid lupus erythematosus and dermatomyositis.

Autor: Kahn JS; Tufts University School of Medicine, Boston, MA, USA.; Department of Dermatology, Tufts Medical Center, Boston, MA, USA., Deverapalli SC; Department of Dermatology, Tufts Medical Center, Boston, MA, USA., Rosmarin DM; Tufts University School of Medicine, Boston, MA, USA.; Department of Dermatology, Tufts Medical Center, Boston, MA, USA.
Jazyk: angličtina
Zdroj: International journal of dermatology [Int J Dermatol] 2018 Aug; Vol. 57 (8), pp. 1007-1014. Date of Electronic Publication: 2018 Jun 05.
DOI: 10.1111/ijd.14064
Abstrakt: Background: Discoid lupus erythematosus (DLE) and dermatomyositis (DM) are inflammatory autoimmune diseases that manifest primarily in the skin but can be linked to systemic complications. Although there is an in-depth understanding of the clinical presentation of these two diseases, much less is known regarding the pathophysiology. This has limited the effective treatment options for patients.
Objective: An understanding of the pathogenesis of each disease in greater detail will lead to newer targeted medications with less morbidity. This review article endeavors to substantiate the use of new treatments which target the JAK-STAT pathway while elaborating on the immunopathology as well.
Methods: PubMed was searched for relevant review articles, case reports, case series reports, randomized clinical trials (RCTs), basic science articles. Appropriate key terms and MeSH terms were utilized in the search. Clinicaltrials.gov was used to find relevant and current clinical trials being conducted in DLE and DM patients.
Results: A review of the literature supports the proposal that though there are likely many components and pathways involved in the destruction of keratinocytes, the Th1 cell immune response and specifically the JAK-STAT signaling pathway is common to both DLE and DM.
Conclusion: Although further study is needed to determine the efficacy and benefits of JAK inhibitors over conventional therapy, these medications should be considered in refractory cases.
(© 2018 The International Society of Dermatology.)
Databáze: MEDLINE
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