Calicivirus co-infections in herpesvirus pneumonia in kittens.

Autor: Monne Rodriguez J; Division of Pathology, School of Veterinary Science, University of Liverpool, UK., Köhler K; Institute of Veterinary Pathology, Faculty of Veterinary Medicine, University of Giessen, Germany., Kipar A; Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, Switzerland; Institute of Global Health, Faculty of Health and Life Sciences, University of Liverpool, UK. Electronic address: anja.kipar@uzh.ch.
Jazyk: angličtina
Zdroj: Veterinary journal (London, England : 1997) [Vet J] 2018 Jun; Vol. 236, pp. 1-3. Date of Electronic Publication: 2018 Apr 09.
DOI: 10.1016/j.tvjl.2018.04.004
Abstrakt: Felid herpesvirus-1 (FeHV-1) and feline calicivirus (FCV) are the most important infectious causes of respiratory disease in cats. FeHV-1 and FCV co-infections are common in cats with upper respiratory tract disease, but it is unknown whether such co-infections also occur in cats with pneumonia. This study examined the lungs of naturally infected cats with FeHV-1 pneumonia for FCV co-infection by histopathology and immunohistochemistry. The frequency of FCV (13/21, 62%) in this group of cats suggests that co-infection is common in kittens with FeHV-1 pneumonia. FCV infected macrophages were often found in the lumen of FeHV-1 affected airways. In 8/13 (62%) cats, typical FCV lesions were distant from changes induced by FeHV-1. FCV infection of type II pneumocytes/alveolar macrophages was apparent in histologically unaltered areas. It is likely that damage to airways induced by FeHV-1 facilitates secondary infection with FCV due to reduced mucociliary clearance and impaired immune defences.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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