Immune oncology, immune responsiveness and the theory of everything.

Autor: Turan T; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Kannan D; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Patel M; Clinical Pharmacology and Pharmacometrics, Abbvie, Redwood City, CA, USA., Matthew Barnes J; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Tanlimco SG; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Lu R; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Halliwill K; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Kongpachith S; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Kline DE; Immune-Oncology, AbbVie, North Chicago, IL, USA., Hendrickx W; Tumor Biology, Immunology, and Therapy Section, Division of Translational Medicine, Research Branch, Sidra Medical and Research Center, Doha, Qatar., Cesano A; Nanostring Technologies, Inc., Seattle, WA, USA., Butterfield LH; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA., Kaufman HL; Departments of Surgery and Medicine, Rutgers University, New Jersey, NJ, USA., Hudson TJ; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Bedognetti D; Tumor Biology, Immunology, and Therapy Section, Division of Translational Medicine, Research Branch, Sidra Medical and Research Center, Doha, Qatar., Marincola F; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA., Samayoa J; Immune-Oncology Discovery, AbbVie, Redwood City, CA, USA. josue.samayoa@abbvie.com.
Jazyk: angličtina
Zdroj: Journal for immunotherapy of cancer [J Immunother Cancer] 2018 Jun 05; Vol. 6 (1), pp. 50. Date of Electronic Publication: 2018 Jun 05.
DOI: 10.1186/s40425-018-0355-5
Abstrakt: Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic and long lasting but occur in a subset of tumors and are largely dependent upon the pre-existing immune contexture of individual cancers. Available data suggest that three landscapes best define the cancer microenvironment: immune-active, immune-deserted and immune-excluded. This trichotomy is observable across most solid tumors (although the frequency of each landscape varies depending on tumor tissue of origin) and is associated with cancer prognosis and response to checkpoint inhibitor therapy (CIT). Various gene signatures (e.g. Immunological Constant of Rejection - ICR and Tumor Inflammation Signature - TIS) that delineate these landscapes have been described by different groups. In an effort to explain the mechanisms of cancer immune responsiveness or resistance to CIT, several models have been proposed that are loosely associated with the three landscapes. Here, we propose a strategy to integrate compelling data from various paradigms into a "Theory of Everything". Founded upon this unified theory, we also propose the creation of a task force led by the Society for Immunotherapy of Cancer (SITC) aimed at systematically addressing salient questions relevant to cancer immune responsiveness and immune evasion. This multidisciplinary effort will encompass aspects of genetics, tumor cell biology, and immunology that are pertinent to the understanding of this multifaceted problem.
Databáze: MEDLINE
Externí odkaz: