Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines.

Autor:	Souza RP; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil., Bonfim-Mendonça PS; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil., Damke GMZF; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil., de-Assis Carvalho ARB; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil., Ratti BA; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil., Dembogurski DSO; Laboratory of Natural Products and Mass Spectrometry (LAPNEM), Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., da-Silva VRS; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil., Silva SO; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil., Da-Silva DB; Laboratory of Natural Products and Mass Spectrometry (LAPNEM), Universidade Federal de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil., Bruschi ML; Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa (UEM), Maringa, Parana, Brazil., Maria-Engler SS; Postgraduate Program in Pharmacy (Physiopathology and Toxicology), Faculty of Pharmacy, University of Sao Paulo (USP), Sao Paulo, SP, Brazil., Consolaro MEL; Postgraduate Program in Biosciences and Pathophysiology, Department of Clinical Analysis and Biomedicine, State University of Maringa (UEM), Maringa, Parana, Brazil.
Jazyk:	angličtina
Zdroj:	Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2018; Vol. 18 (12), pp. 1750-1760.
DOI:	10.2174/1871520618666180604092930
Abstrakt:	Background: Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. Method: To explore a new therapeutic candidate for cervical cancer, we have evaluated the effects of artepillin C on cellular viability in a comprehensive panel of human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16- and 18-positive) and C33A (HPV-negative) cells compared to a spontaneously immortalized human epithelial cell line (HaCaT). Results: Our results demonstrated that artepillin C had a selective effect on cellular viability and could induce apoptosis possibly by intrinsic pathway, likely a result of oxidative stress, in all cancer-derived cell lines but not in HaCaT. Additionally, artepillin C was able to inhibit the migration and invasion of cancer cells. Conclusion: Thus, artepillin C appears to be a promising new candidate as an anticancer drug for cervical cancer induced by different HPV types. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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