N-Substituted Aryl Sulphonamides as Potential Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.
| Autor: | Masand N; Department of Pharmacy, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India., Gupta SP; Department of Applied Sciences, National Institute of Technical Teachers Training & Research, Bhopal (MP), India., Khosa RL; Dr. A. P. J. Abdul Kalam Technical University, BIT, School of Pharmacy, Lucknow, Uttar Pradesh, India. |
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| Jazyk: | angličtina |
| Zdroj: | Current computer-aided drug design [Curr Comput Aided Drug Des] 2018; Vol. 14 (4), pp. 338-348. |
| DOI: | 10.2174/1573409914666180604115425 |
| Abstrakt: | Introduction: A novel series of multifunctional anti-Alzheimer's agents based on Nsubstituted aryl sulphonamides were designed and synthesized. During in vivo moderate to good anti- Alzheimer's Disease (AD) activity was observed as correlated by the modulation of some selected biochemical markers of AD as well as during behavioral assessment. Methods: Among the series, some compounds have shown multi-functional potency by inhibition of Acetylcholinesterase (AChE), Scopolamine induced oxidative stress and were found comparable to the standard drug. Successful modulation of biochemical markers of oxidative stress in AD, displays neuroprotective properties and did not exert any significant toxicity. Results and Conclusion: Thus, the present study has evidently shown that these series of compounds have potential to be optimized as anti-AD agents with multi-functional properties. The aryl sulphonamide nucleus might serve as a promising lead candidate for developing novel anti-AD drug. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| Databáze: | MEDLINE |
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