Synthesis of tritium-labeled cyadox, a promising antimicrobial growth-promoting agent with high specific activity.

Autor: Harnud S; MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, Hubei 430070, P.R. China; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, Hubei 430070, P.R. China; Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China; Hubei Engineering Technology Center for Utilization of Botanical Functional Ingredients, Xiaogan 432000, P.R. China; College of Life Science and Technology,Hubei Engineering University, Xiaogan 432000, P.R. China., Zhang A; Hubei Engineering Technology Center for Utilization of Botanical Functional Ingredients, Xiaogan 432000, P.R. China; College of Life Science and Technology,Hubei Engineering University, Xiaogan 432000, P.R. China., Yuan Z; MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Wuhan, Hubei 430070, P.R. China; National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Wuhan, Hubei 430070, P.R. China; Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Huazhong Agricultural University, Wuhan, Hubei 430070, P.R. China. Electronic address: zonghuiyuan@sina.com.
Jazyk: angličtina
Zdroj: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2018 Sep; Vol. 139, pp. 244-250. Date of Electronic Publication: 2018 May 23.
DOI: 10.1016/j.apradiso.2018.05.018
Abstrakt: Cyadox is a new antimicrobial growth-promoting agent for food-producing animals. Studies on radiolabeled compounds enable the use of sensitive radiometric analytical methods and help in the elucidation of metabolic and elimination pathways. In the present study, 6-[ 3 H]-cyadox with a high specific activity of 2.08 Ci/mmol was prepared by the catalytic bromine-tritium exchange of 4-bromo-2-nitroaniline followed by a three-step microscale synthesis, giving a high yield between 36.16% and 94.75%.
(Copyright © 2018. Published by Elsevier Ltd.)
Databáze: MEDLINE
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