Early Life HIV-1 Immunization: Providing a Window for Protection Before Sexual Debut.

Autor: Permar S; 1 Department of Pediatrics, Duke University Medical School , Durham, North Carolina.; 2 Human Vaccine Institute, Duke University Medical School , Durham, North Carolina., Levy O; 3 Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital , Boston, Massachusetts.; 4 Harvard Medical School , Boston, Massachusetts.; 5 Broad Institute of MIT and Harvard University , Boston, Massachusetts., Kollman TR; 6 Division of Infectious Diseases, Department of Pediatrics, University of British Columbia , Vancouver, Canada ., Singh A; 7 Vaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Rockville, Maryland., De Paris K; 8 Department of Microbiology and Immunology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Jazyk: angličtina
Zdroj: AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2018 Oct; Vol. 34 (10), pp. 823-827. Date of Electronic Publication: 2018 Jul 03.
DOI: 10.1089/AID.2018.0018
Abstrakt: Limited success of current HIV-1 vaccines warrants new approaches. We discuss feasibility and potential benefits of early life HIV-1 immunization followed by vaccine boosts during childhood that may enable maturation of vaccine-induced broad anti-HIV-1 immunity over several years. By initiating this immunization approach in the very young, well before sexual debut, such a strategy may dramatically reduce the risk of HIV-1 infection.
Databáze: MEDLINE