Clinical variables and ethnicity may influenced by polymorphism of CAT -262C/T and MnSOD 47C/T antioxidant enzymes in Algerian type1 diabetes without complications.

Autor: Eddaikra A; Department of Cellular Biology and Physiology, Faculty of Nature and Life, University Saad Dahleb, Blida, Algeria; Department of Cellular and Molecular Biology, Team Cytokines and Nitric Oxide Synthases, Faculty of Biology, University Houari Boumediene USTHB, Algiers, Algeria. Electronic address: aeddaikra@yahoo.fr., Amroun H; Department of Immunology, Institute Pasteur of Algeria, Algiers, Algeria., Raache R; Department of Cellular and Molecular Biology, Team Cytokines and Nitric Oxide Synthases, Faculty of Biology, University Houari Boumediene USTHB, Algiers, Algeria; Department of Immunology, Institute Pasteur of Algeria, Algiers, Algeria., Galleze A; Department of Cellular and Molecular Biology, Team Cytokines and Nitric Oxide Synthases, Faculty of Biology, University Houari Boumediene USTHB, Algiers, Algeria., Abdallah-Elhadj N; Diabetology Department, Trichine Ibrahime Fabore Hospital, Blida, Algeria., Azzouz M; Diabetology Department, Mustapha Pacha Hospital, Algiers, Algeria., Meçabih F; Department of Immunology, Institute Pasteur of Algeria, Algiers, Algeria., Mechti B; Department of Immunology, Institute Pasteur of Algeria, Algiers, Algeria., Abbadi MC; Department of Immunology, Institute Pasteur of Algeria, Algiers, Algeria., Touil-Boukoffa C; Department of Cellular and Molecular Biology, Team Cytokines and Nitric Oxide Synthases, Faculty of Biology, University Houari Boumediene USTHB, Algiers, Algeria., Attal N; Department of Immunology, Institute Pasteur of Algeria, Algiers, Algeria.
Jazyk: angličtina
Zdroj: Gene [Gene] 2018 Sep 05; Vol. 670, pp. 182-192. Date of Electronic Publication: 2018 May 30.
DOI: 10.1016/j.gene.2018.05.105
Abstrakt: The latest studies in Algeria show that the frequency of type 1 diabetes (T1D) without complications is lower than that with complications and represents a significant burden in terms of cost and treatment. For this reason, we are interested in uncomplicated type1 diabetes and risk factors that are related to polymorphisms of antioxidant enzymes in order to prevent its complications. A total of 260 blood samples of young Algerian adults were examined. The genotypic analysis of Catalase gene (CAT -262C/T, rs1001179) and the superoxide dismutase gene (MnSOD 47C/T, rs4880) was performed by real-time PCR using TaqMan technology. The genotypic distribution of the CAT -262C/T promoter gene's polymorphism showed a significant difference between control and T1D patients for the CC genotype (p = 0.009; OR = 0.30) and for the T allele (p = 0.002; OR = 2.82). In addition, the genotypic distribution of the MnSOD 47C/T gene showed an association with T1D for the CT genotype (p = 0.040; OR = 2.37). Our results revealed that polymorphisms of CAT and MnSOD may be associated with physiopathology causing the onset of T1D. Our data, suggest that the genotypic frequencies of these SNPs appear to be influenced by clinical variables and by the Arab-Berber ethnic origin of the Algerian population.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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