A comparison of risk factors for age-related macular degeneration and polypoidal choroidal vasculopathy in Chinese patients.

Autor: Chen XL; Department of Ophthalmology, Fuxing Hospital, Capital Medical University, 20 Street of FuXingMenWai, XiCheng District, Beijing, 100038, China., Hu QR; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen Eye Centre of Xiamen University, Eye Institute of Xiamen University, Medical College of Xiamen University, Xiamen, Fujian Province, China., Bai YJ; ShenZhen Sibionics Co., Ltd, ShenZhen, China., Deng Y; Department of Ophthalmology, Fuxing Hospital, Capital Medical University, 20 Street of FuXingMenWai, XiCheng District, Beijing, 100038, China., Wang HW; Department of Ophthalmology, Fuxing Hospital, Capital Medical University, 20 Street of FuXingMenWai, XiCheng District, Beijing, 100038, China., Liu S; Department of Ophthalmology, Fuxing Hospital, Capital Medical University, 20 Street of FuXingMenWai, XiCheng District, Beijing, 100038, China., Wang YL; Department of Ophthalmology, Fuxing Hospital, Capital Medical University, 20 Street of FuXingMenWai, XiCheng District, Beijing, 100038, China., Yue YK; Department of Ophthalmology, Fuxing Hospital, Capital Medical University, 20 Street of FuXingMenWai, XiCheng District, Beijing, 100038, China. fuxingyk@sina.com.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2018 Aug; Vol. 256 (8), pp. 1449-1457. Date of Electronic Publication: 2018 Jun 01.
DOI: 10.1007/s00417-018-4020-y
Abstrakt: Purpose: Neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) are important vision-threatening diseases worldwide. For effective treatment, the risk factors for the diseases merit investigation. This study aimed to compare the risk factors for nAMD vs. PCV in Chinese patients.
Methods: A total of 946 participants were recruited in this case-control study, including 281 patients with nAMD, 306 patients with PCV, and 359 controls. All participants underwent comprehensive ophthalmic examinations. Information on risk factors were collected by questionnaire. Multivariate logistic regression analyses were performed to investigate the difference in risk factors between nAMD and PCV. In a subgroup of subjects, serum lipid data were obtained and analyzed.
Results: Risk factors for nAMD included older age (OR 1.03, P = 0.001), male gender (OR 1.55, P = 0.020), asthma (OR 2.50, P = 0.028), smoking (OR 1.92, P = 0.001), and family history (OR 6.82, P = 0.001), while smoking (OR 1.67, P = 0.013) was the only risk factor for PCV. Compared to patients with PCV, patients with nAMD were more likely to be older and suffer from hyperlipidemia, coronary artery disease, rheumatism, and tumor. Interestingly, higher levels of high-density lipoprotein were positively associated with PCV in the subgroup analysis (OR 7.74, P = 0.011). Besides, results were quite different between the combination of patients with nAMD and PCV and patients with nAMD or PCV alone.
Conclusions: The risk factors for nAMD and PCV is varying with the exception of smoking. Our findings suggest that different strategies might be applied in the clinical management and scientific research on nAMD and PCV.
Databáze: MEDLINE
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