Particulate matter exposure increases JC polyomavirus replication in the human host.
Autor: | Dolci M; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Carlo Pascal, 36, Milano, Italy., Favero C; EPIGET - Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milan, Via San Barnaba 8, Milano, Italy., Bollati V; EPIGET - Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milan, Via San Barnaba 8, Milano, Italy; Department of Preventive Medicine, Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, Via San Barnaba 8, Milan, Italy., Campo L; Department of Preventive Medicine, Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, Via San Barnaba 8, Milan, Italy., Cattaneo A; Department of Science and High Technology, University of Insubria, Via Valleggio, 11, Como, Italy., Bonzini M; EPIGET - Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community Health, University of Milan, Via San Barnaba 8, Milano, Italy; Department of Preventive Medicine, Fondazione IRCSS Ca' Granda, Ospedale Maggiore Policlinico, Via San Barnaba 8, Milan, Italy., Villani S; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Carlo Pascal, 36, Milano, Italy., Ticozzi R; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Carlo Pascal, 36, Milano, Italy., Ferrante P; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Carlo Pascal, 36, Milano, Italy., Delbue S; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Carlo Pascal, 36, Milano, Italy. Electronic address: Serena.delbue@unimi.it. |
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Jazyk: | angličtina |
Zdroj: | Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2018 Oct; Vol. 241, pp. 234-239. Date of Electronic Publication: 2018 May 29. |
DOI: | 10.1016/j.envpol.2018.05.044 |
Abstrakt: | Background: Human polyomaviruses (HPyVs) asymptomatically infect the human population during childhood and establish latency in the host. Viral reactivation and urinary excretion can occur when the immune system is impaired. Exposure to particulate air pollution, including the PM Objectives: To investigate the relationship between HPyVs viruria and PM Methods: Individual environmental exposure was assessed in 50 healthy adult volunteers using a chemical transport model (CTM) with a municipality resolution for daily PM Results: HPyVs DNA was detected in 54% (median:87.6*10 5 copies/ml) of the urine samples. JCPyV was the prevalent (48%, (median viral load:126*10 5 copies/ml). Considering the load of the most frequently measured HPyVs, JCPyV, in the count-part of the ZINB model, every unitary in PM measured 2 days before urine collection (PM Day -2) was associated with an increase in JCPyV load (PM Conclusions: The environmental levels of PM (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
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