Psychopathology in 7-year-old children with familial high risk of developing schizophrenia spectrum psychosis or bipolar disorder - The Danish High Risk and Resilience Study - VIA 7, a population-based cohort study.

Autor: Ellersgaard D; Mental Health Services - Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jessica Plessen K; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Mental Health Services - Capital Region of Denmark, Child and Adolescent Mental Health Centre, Copenhagen, Denmark., Richardt Jepsen J; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Mental Health Services - Capital Region of Denmark, Child and Adolescent Mental Health Centre, Copenhagen, Denmark.; Mental Health Services - Capital Region of Denmark, Center for Neuropsychiatric Schizophrenia Research and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, Copenhagen, Denmark., Soeborg Spang K; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Mental Health Services - Capital Region of Denmark, Child and Adolescent Mental Health Centre, Copenhagen, Denmark., Hemager N; Mental Health Services - Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Mental Health Services - Capital Region of Denmark, Child and Adolescent Mental Health Centre, Copenhagen, Denmark., Klee Burton B; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Mental Health Services - Capital Region of Denmark, Child and Adolescent Mental Health Centre, Copenhagen, Denmark., Jerlang Christiani C; Mental Health Services - Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gregersen M; Mental Health Services - Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark., Søndergaard A; Mental Health Services - Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark., Uddin MJ; Mental Health Services - Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Department of Public Health - Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark., Poulsen G; Mental Health Services - Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Department of Public Health - Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark., Greve A; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark., Gantriis D; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark., Mors O; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Psychosis Research Unit, Aarhus University Hospital, Aarhus, Denmark., Nordentoft M; Mental Health Services - Capital Region of Denmark, Mental Health Centre Copenhagen, Copenhagen, Denmark.; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Elgaard Thorup AA; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Mental Health Services - Capital Region of Denmark, Child and Adolescent Mental Health Centre, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: World psychiatry : official journal of the World Psychiatric Association (WPA) [World Psychiatry] 2018 Jun; Vol. 17 (2), pp. 210-219.
DOI: 10.1002/wps.20527
Abstrakt: This study aimed to compare the psychopathological profiles of children at familial high risk of schizophrenia spectrum psychosis (FHR-SZ) or bipolar disorder (FHR-BP) with population-based controls. We used Danish nationwide registers to retrieve a cohort of 522 seven-year-old children of parents with schizophrenia spectrum psychosis (N=202), bipolar disorder (N=120) or none of these disorders (N=200). Psychopathology was assessed by reports from multiple informants, including children, parents and teachers. Lifetime DSM-IV diagnoses were ascertained by blinded raters through the Schedule for Affective Disorders and Schizophrenia for School-Age Children. The dimensional assessment of psychopathology was performed by the Child Behavior Checklist, the Teacher's Report Form, a modified version of the ADHD-Rating Scale, the Test Observation Form, and the State-Trait Anxiety Inventory for Children. Current level of functioning was evaluated using the Children's Global Assessment Scale (CGAS). The prevalence of lifetime psychiatric diagnoses was significantly higher in both FHR-SZ children (38.7%, odds ratio, OR=3.5, 95% confidence interval, CI: 2.2-5.7, p < 0.001) and FHR-BP children (35.6%, OR=3.1, 95% CI: 1.8-5.3, p < 0.001) compared with controls (15.2%). FHR-SZ children displayed significantly more dimensional psychopathology on all scales and subscales compared with controls except for the Anxious subscale of the Test Observation Form. FHR-BP children showed higher levels of dimensional psychopathology on several scales and subscales compared with controls, but lower levels compared with FHR-SZ children. Level of functioning was lower in both FHR-SZ children (CGAS mean score = 68.2; 95% CI: 66.3-70.2, p < 0.0001) and FHR-BP children (73.7; 95% CI: 71.2-76.3, p < 0.05) compared with controls (77.9; 95% CI: 75.9-79.9). In conclusion, already at the age of seven, FHR-SZ and FHR-BP children show a higher prevalence of a broad spectrum of categorical and dimensional psychopathology compared with controls. These results emphasize the need for developing early intervention strategies towards this vulnerable group of children.
(© 2018 World Psychiatric Association.)
Databáze: MEDLINE
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