| Autor: |
Santos RS; a Universidade Tiradentes - UNIT , Aracaju , Brazil.; b Instituto de Tecnologia e Pesquisa Laboratório de Nanotecnologia e Nanomedicina (LNMed) Av. Murilo Dantas , Aracaju , Brazil., Loureiro KC; a Universidade Tiradentes - UNIT , Aracaju , Brazil.; b Instituto de Tecnologia e Pesquisa Laboratório de Nanotecnologia e Nanomedicina (LNMed) Av. Murilo Dantas , Aracaju , Brazil., Rezende PS; a Universidade Tiradentes - UNIT , Aracaju , Brazil.; b Instituto de Tecnologia e Pesquisa Laboratório de Nanotecnologia e Nanomedicina (LNMed) Av. Murilo Dantas , Aracaju , Brazil., Andrade LN; a Universidade Tiradentes - UNIT , Aracaju , Brazil.; b Instituto de Tecnologia e Pesquisa Laboratório de Nanotecnologia e Nanomedicina (LNMed) Av. Murilo Dantas , Aracaju , Brazil., de Melo Barbosa R; c Department of Pharmacy, Faculty of Pharmacy, Federal University of Rio Grande do Norte , Petrópolis , Brazil., Santini A; d Department of Pharmacy, University of Napoli 'Federico II' , Napoli , Italy., Santos AC; e Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC) Polo das Ciências da Saúde Azinhaga de Santa Comba , Coimbra , Portugal.; f Institute for Innovation and Health Research, Group Genetics of Cognitive Dysfunction, Institute for Molecular and Cell Biology , Porto , Portugal., Ferreira da Silva C; g Biotechnology Laboratory of Natural Products (BIONAT), Institute of Environmental Sciences, Chemical and Pharmaceutical, Federal University of São Paulo , Diadema , Brazil., Souto EB; e Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC) Polo das Ciências da Saúde Azinhaga de Santa Comba , Coimbra , Portugal.; h REQUIMTE/LAQV Group of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra , Coimbra , Portugal., de Sousa DP; i Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba , Paraíba , Brazil., Amaral RG; j Departamento de Fisiologia, Universidade Federal de Sergipe , São Cristovão , Brazil., Severino P; a Universidade Tiradentes - UNIT , Aracaju , Brazil.; b Instituto de Tecnologia e Pesquisa Laboratório de Nanotecnologia e Nanomedicina (LNMed) Av. Murilo Dantas , Aracaju , Brazil. |
| Abstrakt: |
Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery, overcoming the problems of low bioavailability and high toxicity of these drugs. Due to their unique features, namely the small mean particle size, nanoparticles contribute to the enhanced drug absorption and uptake by the target cells, potentiating the therapeutic drug effect. The topical route is desirable due to the adverse effects arising from oral administration. This review provides a comprehensive analysis of the use of nano compounds for the current treatment of topical fungal infections. A special emphasis is given to the employment of lipid nanoparticles, due to their recognized efficacy, versatility, and biocompatibility, attracting the major attention as novel topical nanocompounds used for the administration of antifungal drugs. |
