Test-retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamic 11 C-acetate PET and multimodality approaches in healthy controls.

Autor: Hansson NH; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. nilhan@rm.dk., Harms HJ; Department of Nuclear Medicine & PET-Center, Aarhus University Hospital, Aarhus, Denmark., Kim WY; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Nielsen R; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Tolbod LP; Department of Nuclear Medicine & PET-Center, Aarhus University Hospital, Aarhus, Denmark., Frøkiær J; Department of Nuclear Medicine & PET-Center, Aarhus University Hospital, Aarhus, Denmark., Bouchelouche K; Department of Nuclear Medicine & PET-Center, Aarhus University Hospital, Aarhus, Denmark., Poulsen SH; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Wiggers H; Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark., Parner ET; Section for Biostatistics, Department of Public Health, Aarhus University, Aarhus, Denmark., Sörensen J; Department of Nuclear Medicine & PET-Center, Aarhus University Hospital, Aarhus, Denmark.
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2018 Dec; Vol. 25 (6), pp. 1929-1936. Date of Electronic Publication: 2018 May 31.
DOI: 10.1007/s12350-018-1302-z
Abstrakt: Background: Myocardial efficiency measured by 11 C-acetate positron emission tomography (PET) has successfully been used in clinical research to quantify mechanoenergetic coupling. The objective of this study was to establish the repeatability of myocardial external efficiency (MEE) and work metabolic index (WMI) by non-invasive concepts.
Methods and Results: Ten healthy volunteers (63 ± 4 years) were examined twice, one week apart, using 11 C-acetate PET, cardiovascular magnetic resonance (CMR), and echocardiography. Myocardial oxygen consumption from PET was combined with stroke work data from CMR, echocardiography, or PET to obtain MEE and WMI for each modality. Repeatability was estimated as the coefficient of variation (CV) between test and retest. MEE CMR , MEE Echo , and MEE PET values were 21.9 ± 2.7%, 16.4 ± 3.7%, and 23.8 ± 4.9%, respectively, P < .001. WMI CMR , WMI Echo , and WMI PET values were 4.42 ± 0.90, 4.07 ± 0.63, and 4.58 ± 1.13 mmHg × mL/m 2  × 10 6 , respectively, P = .45. Repeatability for MEE CMR was superior compared with MEE Echo but did not differ significantly compared with MEE PET (6.3% vs 12.9% and 9.4%, P = .04 and .25). CV values for WMI CMR , WMI Echo , and WMI PET were 10.0%, 14.8%, and 12.0%, respectively, (P = .53).
Conclusions: Non-invasive measurements of MEE using 11 C-acetate PET are highly repeatable. A PET-only approach did not differ significantly from CMR/PET and might facilitate further clinical research due to lower costs and broader applicability.
Databáze: MEDLINE
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