| Autor: |
Scheid T; Department of Physiology, Institute of Basic Health Sciences, University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Moraes MS; Department of Physiology, Institute of Basic Health Sciences, University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Henriques TP; Department of Physiology, Institute of Basic Health Sciences, University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Riffel APK; Department of Physiology, Institute of Basic Health Sciences, University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Belló-Klein A; Department of Physiology, Institute of Basic Health Sciences, University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Poser GLV; Institute of Pharmacy, University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil., Ethur EM; Department of Exact and Technological Sciences, UNIVATES, Lajeado, RS, Brazil., Partata WA; Department of Physiology, Institute of Basic Health Sciences, University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. |
| Abstrakt: |
We determined the antioxidant potential of fractions obtained from leaves of Schinus terebinthifolius , a medicinal plant known in Brazil as aroeira, to select the fraction with the best yield and antioxidant performance. These qualities were found in the methanol fraction (MeF), which was administered intraperitoneally (20 mg/kg/day) for 3 and 10 days to rats with chronic constriction injury (CCI) of the sciatic nerve, a model of neuropathic pain. The MeF increased the mechanical and thermal thresholds that had been lowered by CCI. In parallel, the lumbosacral spinal cord showed an increase in superoxide dismutase but a decrease in glutathione peroxidase and glutathione-S-transferase activities in saline- and MeF-treated CCI rats. Catalase activity decreased only in saline-treated CCI rats for 10 days. Total thiols decreased in saline- and MeF-treated CCI rats. Ascorbic acid increased in these rats at day 3 but only in saline-treated CCI rats at day 10. No change was found in hydrogen peroxide and lipid hydroperoxide. Open-field and elevated plus-maze tests and blood parameters of liver function did not change. Thus, the MeF from leaves of S. terebinthifolius has an antinociceptive action with no toxic effects, and it affects oxidant biomarkers in the spinal cord of rats with CCI. |
Plný text