The Prevalence of Phenylketonuria in Arab Countries, Turkey, and Iran: A Systematic Review.

Autor: El-Metwally A; King Abdullah International Medical Research Center (KAIMRC) and College of Public Health and Health Informatics, King Saud Bin AbdulAziz University for Health Sciences, Riyadh, Saudi Arabia.; Department of Epidemiology, School of Health Sciences, University of Tampere, Tampere, Finland., Yousef Al-Ahaidib L; Newborn Screening and Biochemical Genetics Lab, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia., Ayman Sunqurah A; King Abdullah International Medical Research Center (KAIMRC) and College of Public Health and Health Informatics, King Saud Bin AbdulAziz University for Health Sciences, Riyadh, Saudi Arabia., Al-Surimi K; King Abdullah International Medical Research Center (KAIMRC) and College of Public Health and Health Informatics, King Saud Bin AbdulAziz University for Health Sciences, Riyadh, Saudi Arabia., Househ M; King Abdullah International Medical Research Center (KAIMRC) and College of Public Health and Health Informatics, King Saud Bin AbdulAziz University for Health Sciences, Riyadh, Saudi Arabia., Alshehri A; King Abdullah International Medical Research Center (KAIMRC) and College of Public Health and Health Informatics, King Saud Bin AbdulAziz University for Health Sciences, Riyadh, Saudi Arabia., Da'ar OB; King Abdullah International Medical Research Center (KAIMRC) and College of Public Health and Health Informatics, King Saud Bin AbdulAziz University for Health Sciences, Riyadh, Saudi Arabia., Abdul Razzak H; Ministry of Health and Prevention, Dubai, UAE., AlOdaib AN; Newborn Screening and Biochemical Genetics Lab, Research Center, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.; King Salman Center for Disability Research, Riyadh, Saudi Arabia.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2018 Apr 18; Vol. 2018, pp. 7697210. Date of Electronic Publication: 2018 Apr 18 (Print Publication: 2018).
DOI: 10.1155/2018/7697210
Abstrakt: Background/objectives: This paper seeks to identify the prevalence of Phenylketonuria (PKU) in Arab countries, Turkey, and Iran. The study reviewed the existence of comprehensive national newborn screening programs and reported consanguinity rates.
Methods: A computer based literature search was conducted using relevant keywords to retrieve studies conducted on PKU. A total of 34 articles were included. Prevalence was categorized based on the type of screening method used for PKU diagnoses.
Results: The prevalence of classical PKU diagnosed through a comprehensive national newborn screening program ranged from 0.005% to 0.0167%. The highest prevalence was reported in Turkey at 0.0167%, whereas the lowest prevalence was reported in the UAE, 0.005%.
Conclusion: The findings of this review emphasize the need for the establishment of more efficient reporting systems in these countries that would help measure Disability-Adjusted Life Year (DALY) in order to estimate the overall societal burden of PKU.
Databáze: MEDLINE
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