Extended low oxygen transmissibility contact lens use induces alterations in the concentration of proinflammatory cytokines, enzymes and electrolytes in tear fluid.

Autor: Barba Gallardo LF; Optometry Department, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico., Muñoz Ortega MH; Chemistry Department, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico., Ventura Juarez J; Morphology Department, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico., Aldaba Muruato LR; Morphology Department, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico., Sánchez Alemán E; Chemistry Department, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico., Valdez Morales EE; CONACYT-Department of Surgery and Molecular Diagnosis Laboratory, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico., Blancas Zugarazo SS; CONACYT-Department of Surgery and Molecular Diagnosis Laboratory, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico., Villafan Bernal JR; CONACYT-Department of Surgery and Molecular Diagnosis Laboratory, Autonomous University of Aguascalientes, Aguascalientes 20131, Mexico.
Jazyk: angličtina
Zdroj: Experimental and therapeutic medicine [Exp Ther Med] 2018 May; Vol. 15 (5), pp. 4291-4297. Date of Electronic Publication: 2018 Mar 22.
DOI: 10.3892/etm.2018.5989
Abstrakt: Prolonged and continuous use of contact lenses for as long as 3 or 4 weeks is common in Mexico due to the low socioeconomic status, poor patient education and self-neglect. Furthermore, wearing contact lenses with low oxygen permeability is common due to their low cost. Thus, patients seek ophthalmologic evaluation due to signs and symptoms of overuse such as red eye, discomfort and tearing. In the present study, the effect of wearing soft contact lenses with a low oxygen permeability on the tear fluid composition after 1 day, 1 week and 1 month without removing them was examined. In this prospective clinical trial, several tear fluid biomarkers were measured in 84 non-adapted contact lens wearers (NACLWs), including the pH, electrolytes, osmolarity, pro-inflammatory molecules [interleukin (IL)-8, IL-1β and interferon (IFN)-γ], total protein (TP) levels and enzymes [aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and alkaline phosphatase (AP)]. The results indicated that the tear pH was significantly decreased after 1 day and 1 week; however, after 1 month of use, the tear pH level returned to the baseline. Tear electrolyte analysis demonstrated a significant decrease in Na + at 1 day, 1 week and 1 month and Cl - levels at 1 week and 1 month, and a significant increase in Ca 2+ at 1 week and 1 month, K + at 1 day, 1 week and 1 month, IL-8 at 1 week and 1 month, IL-1β only at 1 week and IFN-γ at 1 week and 1 month. Furthermore, the study observed an elevation of TP, AST, LDH and AP levels, however, there were no significant changes in ALT. In conclusion, the current study revealed that continuous wearing of soft contact lenses with low oxygen permeability increase tear fluid proinflammatory cytokine levels and enzymes reflecting tissue damage.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje