Clozapine Intoxication Mimicking Acute Stroke.

Autor: Lebin JA; University of Washington, Department of Emergency Medicine, Seattle, Washington., Villarreal JD; University of Washington, Department of Pharmacy, Seattle, Washington., Chen BC; University of Washington, Department of Emergency Medicine, Seattle, Washington., Hall MK; University of Washington, Department of Emergency Medicine, Seattle, Washington.
Jazyk: angličtina
Zdroj: Clinical practice and cases in emergency medicine [Clin Pract Cases Emerg Med] 2018 Apr 05; Vol. 2 (2), pp. 155-157. Date of Electronic Publication: 2018 Apr 05 (Print Publication: 2018).
DOI: 10.5811/cpcem.2018.1.36734
Abstrakt: Clozapine is an atypical antipsychotic drug prescribed for treatment-resistant schizophrenia. The risk of adverse hematologic, cardiovascular, and neurologic effects has tempered its use, and reports of overdoses remain rare. We report a case of accidental acute clozapine intoxication in a clozapine-naïve patient, who presented with symptoms mimicking acute stroke and later developed status epilepticus. Clozapine intoxication is a rare presentation in the emergency department with potential for iatrogenic harm if not correctly identified.
Competing Interests: Conflicts of Interest: By the CPC-EM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. The authors disclosed none.
Databáze: MEDLINE