Comparison of EORTC QLQ-C30 and PRO-CTCAE™ Questionnaires on Six Symptom Items.

Autor: Taarnhøj GA; Department of Oncology, Rigshospitalet, Copenhagen, Denmark. Electronic address: gry.assam.taarnhoej@regionh.dk., Kennedy FR; Leeds Institute of Cancer and Pathology, School of Medicine, University of Leeds, Leeds, United Kingdom., Absolom KL; Leeds Institute of Cancer and Pathology, School of Medicine, University of Leeds, Leeds, United Kingdom., Bæksted C; Documentation & Quality, Danish Cancer Society, Copenhagen, Denmark., Vogelius IR; Department of Oncology, Rigshospitalet, Copenhagen, Denmark., Johansen C; Department of Oncology, Rigshospitalet, Copenhagen, Denmark., Velikova G; Leeds Institute of Cancer and Pathology, School of Medicine, University of Leeds, Leeds, United Kingdom., Pappot H; Department of Oncology, Rigshospitalet, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: Journal of pain and symptom management [J Pain Symptom Manage] 2018 Sep; Vol. 56 (3), pp. 421-429. Date of Electronic Publication: 2018 May 25.
DOI: 10.1016/j.jpainsymman.2018.05.017
Abstrakt: Context: Clinical studies have over the past decade paid increasing attention to health-related quality of life data. Multiple questionnaires are often administered resulting in overlapping questions increasing patient burden.
Objectives: To examine the correlations between the commonly used European Organization for Research and Treatment of Cancer Quality of Life Questionnnaire-C30 (QLQ-C30) and the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) on six coinciding items to determine consistency between overlapping items.
Methods: Data were prospectively collected from patients attending two cancer centers in the U.K. Participants completed the QLQ-C30 version 3.0 every four weeks and the PRO-CTCAE at least once a week for 12 weeks. Data were collected via the Internet or an interactive voice response. For the six coinciding items in QLQ-C30 and PRO-CTCAE: pain, nausea, vomiting, constipation, diarrhea, and fatigue, comparisons were made between all possible related responses by aligning the four responses in the QLQ-C30 with two condensed versions of the five responses in the PRO-CTCAE. Consistency and reliability was determined with the intraclass correlation coefficient (ICC) and Cronbach's α.
Results: About 247 patients completed 785 QLQ-C30 and 2501 PRO-CTCAE questionnaires. Moderate (ICC >0.5) to good (ICC >0.75) reliability and Cronbach's α >0.7 were found on all coinciding questions except for questions concerning the severity of nausea and vomiting as a result of relatively few patients responding to these questions. Items on frequency showed better correlations than the severity and interference items.
Conclusion: The good reliability and consistency between the QLQ-C30 and PRO-CTCAE support future attempts to minimize patient burden by shortening health-related quality of life questionnaires.
(Copyright © 2018 American Academy of Hospice and Palliative Medicine. All rights reserved.)
Databáze: MEDLINE
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