Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle.

Autor:	Hirako IC; Laboratory of Immunopathology, Fundação Oswaldo Cruz - Minas, Belo Horizonte, Minas Gerais 30190-002, Brazil; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-4321, USA., Assis PA; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-4321, USA., Hojo-Souza NS; Laboratory of Immunopathology, Fundação Oswaldo Cruz - Minas, Belo Horizonte, Minas Gerais 30190-002, Brazil., Reed G; Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, MA 01605-4321, USA., Nakaya H; Escola de Ciências Farmacêuticas - Universidade de São Paulo, São Paulo 05508-000, Brazil., Golenbock DT; Laboratory of Immunopathology, Fundação Oswaldo Cruz - Minas, Belo Horizonte, Minas Gerais 30190-002, Brazil; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-4321, USA., Coimbra RS; Laboratory of Immunopathology, Fundação Oswaldo Cruz - Minas, Belo Horizonte, Minas Gerais 30190-002, Brazil., Gazzinelli RT; Laboratory of Immunopathology, Fundação Oswaldo Cruz - Minas, Belo Horizonte, Minas Gerais 30190-002, Brazil; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-4321, USA; Departamento de Bioquímica e Imunologia - Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil; Plataforma de Medicina Translacional, Fundação Oswaldo Cruz/Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, São Paulo 14049-900, Brazil. Electronic address: ricardo.gazzinelli@umassmed.edu.
Jazyk:	angličtina
Zdroj:	Cell host & microbe [Cell Host Microbe] 2018 Jun 13; Vol. 23 (6), pp. 796-808.e6. Date of Electronic Publication: 2018 May 24.
DOI:	10.1016/j.chom.2018.04.016
Abstrakt:	The Plasmodium cell cycle, wherein millions of parasites differentiate and proliferate, occurs in synchrony with the vertebrate host's circadian cycle. The underlying mechanisms are unknown. Here we addressed this question in a mouse model of Plasmodium chabaudi infection. Inflammatory gene expression and carbohydrate metabolism are both enhanced in interferon-γ (IFNγ)-primed leukocytes and liver cells from P. chabaudi-infected mice. Tumor necrosis factor α (TNFα) expression oscillates across the host circadian cycle, and increased TNFα correlates with hypoglycemia and a higher frequency of non-replicative ring forms of trophozoites. Conversely, parasites proliferate and acquire biomass during food intake by the host. Importantly, cyclic hypoglycemia is attenuated and synchronization of P. chabaudi stages is disrupted in IFNγ -/- , TNF receptor -/- , or diabetic mice. Hence, the daily rhythm of systemic TNFα production and host food intake set the pace for Plasmodium synchronization with the host's circadian cycle. This mechanism indicates that Plasmodium parasites take advantage of the host's feeding habits. (Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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