Adiponectin is related to markers of endothelial dysfunction and neoangiogenesis in diabetic patients.

Autor: Kacso T; 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babes Street, 400000, Cluj-Napoca, Romania., Bondor CI; Department of Informatics and Biostatistics, 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 6 Pasteur Street, 400349, Cluj-Napoca, Romania., Rusu CC; Department of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania., Moldovan D; Department of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania., Trinescu D; Department of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania., Coman LA; Department of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania., Ticala M; Department of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania., Gavrilas AM; 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 8 Victor Babes Street, 400000, Cluj-Napoca, Romania. alexandra.gavrilas95@yahoo.com., Potra AR; Department of Nephrology, 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca, 3-5 Clinicilor Street, 400006, Cluj-Napoca, Romania.
Jazyk: angličtina
Zdroj: International urology and nephrology [Int Urol Nephrol] 2018 Sep; Vol. 50 (9), pp. 1661-1666. Date of Electronic Publication: 2018 May 26.
DOI: 10.1007/s11255-018-1890-1
Abstrakt: Purpose: Adiponectin an adipokine, produced by mature adipocyte, has an important effect on several aspects of endothelial function, including leukocyte adhesion (mediated by adhesion molecules like intercellular adhesion molecule 1 (ICAM1) endothelial cell selective adhesion molecule ESAM). Recently, it has been linked to vascular endothelial growth factor (VEGF)-modulated angiogenesis. ESAM might also be involved in modulating VEGF-dependent actions. We studied relationship of adiponectin to ESAM, ICAM1, and VEGF in type 2 diabetic patients (T2DP) with or without microvascular complications.
Methods: Incident T2DP referred for nephrologic evaluation were included (patients with no nephropathy or stage 1-4 nephropathy). T2DP with stage 5 chronic kidney disease (CKD) were selected from a dialysis center. Clinical, standard laboratory assessment and adiponectin, ESAM, ICAM1, and VEGF (ELISA) were recorded.
Results: Eighty-seven patients were included, 15 had no CKD, 30 with stage 1 or 2 CKD, 20 with stage 3 or 4 CKD and 22 patients on dialysis. ESAM was higher in patients with CKD than in those without CKD (p = 0.02), adiponectin, ICAM1, and VEGF were similar. Adiponectin correlated in univariate analysis to ESAM (r = 0.32, p = 0.002), ICAM1 (r = 0.23, p = 0.038), and CRP (r = 0.31, p = 0.012), and inversely to serum albumin (r = - 0.57, < 0.0001). In predialysis patients, adiponectin also correlated to albuminuria (r = 0.54, p < 0.0001) and glomerular filtration rate (r = - 0.46, p = 0.0001). In multivariate regression ESAM (p = 0.04), VEGF (p = 0.03), and albumin (p < 0.0001) are significant predictors of adiponectin. None of these cytokines were different when comparing patients with and without retinopathy.
Conclusion: Adiponectin is directly linked to adhesion molecules and VEGF in T2DP.
Databáze: MEDLINE
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