Evaluation of the antimicrobial efficacy and skin safety of a novel color additive in combination with chlorine disinfectants.

Autor: Tyan K; Kinnos Inc., 760 Parkside Avenue, Suite 215, Brooklyn, NY 11226. Electronic address: kevin@kinnos.us., Kang J; Kinnos Inc., 760 Parkside Avenue, Suite 215, Brooklyn, NY 11226., Jin K; Kinnos Inc., 760 Parkside Avenue, Suite 215, Brooklyn, NY 11226., Kyle AM; Department of Biomedical Engineering, Columbia University, New York, New York.
Jazyk: angličtina
Zdroj: American journal of infection control [Am J Infect Control] 2018 Nov; Vol. 46 (11), pp. 1254-1261. Date of Electronic Publication: 2018 May 24.
DOI: 10.1016/j.ajic.2018.04.223
Abstrakt: Objective: A novel color additive colorizes chlorine disinfectants blue to improve visibility and enhance spray surface coverage, and it fades to colorless to indicate elapsed contact time. We investigated its interactions with 3 chlorine disinfectants to determine if the additive would adversely affect the disinfectants' antimicrobial efficacy or skin safety.
Methods: We tested 0.5% sodium hypochlorite, 0.2% calcium hypochlorite, and 0.5% sodium dichloroisocyanurate (NaDCC) alone versus with color additive. An independent laboratory tested efficacy against Staphylococcus aureus, Pseudomonas aeruginosa, Vibrio cholerae, and human coronavirus 229E. An independent laboratory also tested direct skin irritation.
Results: Chlorine disinfectants with and without color additive achieved equal levels of efficacy against the tested pathogens. Against S. aureus, 0.5% sodium hypochlorite with and without color additive met Environmental Protection Agency criteria for disinfection success. Against human coronavirus 229E, 0.5% sodium hypochlorite alone failed disinfection success criteria, whereas 0.5% sodium hypochlorite with color additive achieved full viral inactivation (≥4.50 log 10 reduction). Against V. cholerae, 0.2% calcium hypochlorite alone and with color additive achieved 5.99 log 10 and >6.03 log 10 reductions, respectively. Against S. aureus and P. aeruginosa, 0.5% NaDCC with and without color additive achieved >4.9 log 10 and >3.54 log 10 reductions, respectively. All 3 chlorine disinfectants with color additive tested as negligible skin irritants.
Conclusions: This color additive can be combined with chlorine disinfectants without adversely affecting antimicrobial efficacy or skin safety.
(Copyright © 2018 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: