Cortical excitability variability: Insights into biological and behavioral characteristics of healthy individuals.

Autor: Chagas AP; Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Physical Therapy Department, Av. Prof Moraes Rego s/n 50670-900, Recife, Brazil., Monteiro M; Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Physical Therapy Department, Av. Prof Moraes Rego s/n 50670-900, Recife, Brazil., Mazer V; Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Physical Therapy Department, Av. Prof Moraes Rego s/n 50670-900, Recife, Brazil., Baltar A; Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Physical Therapy Department, Av. Prof Moraes Rego s/n 50670-900, Recife, Brazil., Marques D; Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Physical Therapy Department, Av. Prof Moraes Rego s/n 50670-900, Recife, Brazil., Carneiro M; Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Physical Therapy Department, Av. Prof Moraes Rego s/n 50670-900, Recife, Brazil., Rodrigues de Araújo MDG; Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Physical Therapy Department, Av. Prof Moraes Rego s/n 50670-900, Recife, Brazil., Piscitelli D; School of Physical and Occupational Therapy, McGill University, Montreal, Canada; School of Medicine and Surgery, Neuroscience, University of Milan-Bicocca, Milan, Italy., Monte-Silva K; Applied Neuroscience Laboratory, Universidade Federal de Pernambuco, Physical Therapy Department, Av. Prof Moraes Rego s/n 50670-900, Recife, Brazil. Electronic address: katia.kmsilva@ufpe.br.
Jazyk: angličtina
Zdroj: Journal of the neurological sciences [J Neurol Sci] 2018 Jul 15; Vol. 390, pp. 172-177. Date of Electronic Publication: 2018 Apr 22.
DOI: 10.1016/j.jns.2018.04.036
Abstrakt: Motor threshold (MT) measured by transcranial magnetic stimulation (TMS) has diagnostic utility in central nervous system disorders. Its diagnostic sensitivity may be enhanced by identification of non-pathological factors which may influence this measure. The aim of this study was to provide a description of MT variability across physiological and non-pathological behaviour characteristics in a large cohort, including hemispheric asymmetries. In a cross-sectional study, age, handedness, physical activity level, body mass index, gender/menstrual cycle phase, glycemic index and degree of stress were collected from 115 healthy participants. The resting MT of the first dorsal interosseous muscle to TMS was recorded in both hemispheres and served as an indicator of the cortical excitability level. Repeated measures ANOVAs revealed higher MT values in the non-dominant hemisphere, elderly people, stressed individuals and women with amenorrhea. Other biological and behavioral individual characteristics did not influence cortical excitability. Although the degree of interhemispheric difference varied (range: 0.2 to 4.3), depending on biological and behavioral characteristics, this variation was not significant (0.1 ≤ p ≤ 0.8). In conclusion, MT varied considerably between subjects. The difference between the hemisphere excitability that was less influenced by external factors, may be an alternative method of TMS measure to identify pathological changes of cortical excitability.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: