Cyclic nigerosyl-1,6-nigerose-based nanosponges: An innovative pH and time-controlled nanocarrier for improving cancer treatment.

Autor: Caldera F; Dipartimento di Chimica-Università di Torino, Via P. Giuria 7, 10125 Torino, Italy., Argenziano M; Dipartimento di Scienza e Tecnologia del Farmaco-Università di Torino, Via P. Giuria 9, 10125 Torino, Italy., Trotta F; Dipartimento di Chimica-Università di Torino, Via P. Giuria 7, 10125 Torino, Italy., Dianzani C; Dipartimento di Scienza e Tecnologia del Farmaco-Università di Torino, Via P. Giuria 9, 10125 Torino, Italy., Gigliotti L; Dipartimento di Scienze della Salute, UPO, Via Solaroli 17, 28100 Novara, Italy., Tannous M; Dipartimento di Chimica-Università di Torino, Via P. Giuria 7, 10125 Torino, Italy., Pastero L; Dipartimento di Scienze della Terra, Università di Torino, Via V. Caluso 35, 10125 Torino, Italy., Aquilano D; Dipartimento di Scienze della Terra, Università di Torino, Via V. Caluso 35, 10125 Torino, Italy., Nishimoto T; Division Manager New Material Development Division R&D Center Hayashibara Co., Ltd. 675-1 Fujisaki, Naka-ku, Okayama 702-8006, Japan., Higashiyama T; NAGASE (EUROPA) GmbH/Hayashibara-Immermannstrasse 65c, 40210 Düsseldorf, Germany., Cavalli R; Dipartimento di Scienza e Tecnologia del Farmaco-Università di Torino, Via P. Giuria 9, 10125 Torino, Italy. Electronic address: roberta.cavalli@unito.it.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2018 Aug 15; Vol. 194, pp. 111-121. Date of Electronic Publication: 2018 Apr 06.
DOI: 10.1016/j.carbpol.2018.04.027
Abstrakt: The design and structural optimisation of a novel polysaccharide-based nanomaterial for the controlled and sustained release of doxorubicin are here reported. A cross-linked polymer was obtained by reacting a tetraglucose, named cyclic nigerosyl-1-6-nigerose (CNN), with pyromellitic dianhydride. The cross-linking reaction formed solid nanoparticles, named nanosponges, able to swell as a function of the pH. Nanoparticle sizes were reduced using High Pressure Homogenization, to obtain uniform nanosuspensions. Doxorubicin was incorporated into the CNN-nanosponges in a good extent. DSC and solid state NMR analyses proved the drug interaction with the polymer matrix. In vitro studies demonstrated pH-dependent slow and prolonged release kinetics of the drug from the nanoformulation. Doxorubicin-loaded CNN-nanosponges were easily internalized in A2780 cell line. They might considered an intracellular doxorubicin reservoir, able to slowly release the drug over time. CNN-nanosponges may be promising biocompatible nanocarriers for the sustained delivery of doxorubicin with potential localised application in cancer treatments.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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