Gender-specific association between Apelin/APJ gene polymorphisms and hypertension risk in Southeast China.
Autor: | Wu XD; Department of Anesthesiology, Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian Medical University, Fuzhou, Fujian 350001, China., Zhang N; Department of Anesthesiology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China., Liang M; Department of Anesthesiology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China., Liu WL; College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine & Fujian Rehabilitation Engineering Research Center, Fuzhou, Fujian 350108, China., Lin BB; College of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine & Fujian Rehabilitation Engineering Research Center, Fuzhou, Fujian 350108, China., Xiao YR; Department of Anesthesiology, the Ninety-second Hospital of Nanping, Nanping, Fujian 353000, China., Li YZ; Department of Anesthesiology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China., Zeng K; Department of Anesthesiology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China. Electronic address: fymzk6822@163.com., Lin CZ; Department of Anesthesiology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian 350005, China. |
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Jazyk: | angličtina |
Zdroj: | Gene [Gene] 2018 Aug 30; Vol. 669, pp. 63-68. Date of Electronic Publication: 2018 May 22. |
DOI: | 10.1016/j.gene.2018.05.079 |
Abstrakt: | To explore the role of genetic factors in the pathogenesis of hypertension, our study investigated the gender-specific association between four polymorphisms in the Apelin/APJ gene and hypertension risk in southeastern Chinese population. All participants including 645 hypertensive patients and 362 normotensive controls were genotyped for 4 gene polymorphisms associated with hypertension susceptibility including Apelin (rs909656, rs5975126) and APJ (rs10501367, rs11544374). According to genotype analysis, for male subjects, the frequencies of genotypes (P = 0.046 and 0.046, respectively) of rs10501367 and rs11544374 revealed significant differences between the hypertension and control groups. Moreover, for female subjects, there was significant difference on the genotype distribution of rs11544374 between two groups (P = 0.046). The association of rs10501367 with hypertension was significant for males under additive models and recessive models, even after adjusting for age, BMI, fasting glucose and waistline. Besides, significant association was observed for rs11544374 in females under additive models. As for haplotype analysis, haplotype T-A (in order of rs10501367 and rs11544374) in APJ gene was marginally overrepresented in controls (17.9%) compared to patients with hypertension (11.6%) in males (P = 0.003). The mutation of polymorphism rs10501367 in APJ gene decreased risk of hypertension in Chinese males. (Copyright © 2018 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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