[The efficacy of systemic thrombolysis in patients with cardioembolic stroke].

Autor:	Kotov SV; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Isakova EV; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Belova YA; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Zmislinskiy AV; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Kolchu IG; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Kucheryavaya MV; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Pustinnikov YA; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Smetana LV; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Sashin VV; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia., Chernih NP; Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2018; Vol. 118 (3. Vyp. 2), pp. 57-60.
DOI:	10.17116/jnevro20181183257-60
Abstrakt:	Aim: To compare the efficacy and safety of systemic thrombolytic therapy (STLT) in patients with cardioembolic stroke (CE) versus other pathogenic subtypes of ischemic stroke (IS). Material and Methods: The study included 147 patients, 62 women and 85 men (mean age - 62.9±0.8 years) including 37 patients (25.2%) with CE subtype of IS (group 1) and 110 patients with other pathogenetic subtypes of IS (group 2). NIHSS and Rankin scale were used to assess patient's neurological status. Results: One hundred and twenty-six patients were discharged, 21 (14.3%) died. In 11 patients, the cause of death was the development of symptomatic hemorrhagic transformation (SHT). There were no significant differences in the lethality between groups 1 and 2. Tolerability to STLT in these groups did not differ as well. As a result of treatment, the condition of patients surviving to the end of the hospital stay improved, which was reflected in a significant decrease in the NIHSS scores, despite the higher NIHSS scores in group 1. Conclusion: The results confirm the efficacy of STLT in patients with CE IS and indicate the increase in the frequency of favorable functional recovery in these patients.
Databáze:	MEDLINE
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