Use of Mesenchymal Stem Cells for Possible Repair of Doxorubicin-Damaged Organs and Tissues in Experimental Monkeys.

Autor: Agrba VZ; Research Institute of Medical Primatology, Sochi, Russia. agrba_vz@mail.ru., Karal-Ogly DD; Research Institute of Medical Primatology, Sochi, Russia., Gvozdik TE; Research Institute of Medical Primatology, Sochi, Russia., Kaplanyan PA; Research Institute of Medical Primatology, Sochi, Russia., Demenkova NP; Research Institute of Medical Primatology, Sochi, Russia., Gvaramiya IA; Research Institute of Medical Primatology, Sochi, Russia., Mukhametzyanova EI; Research Institute of Medical Primatology, Sochi, Russia., Shamsutdinova OA; Research Institute of Medical Primatology, Sochi, Russia., Chuguev YP; Research Institute of Medical Primatology, Sochi, Russia., Kal'sina SS; Research Institute of Medical Primatology, Sochi, Russia., Konoplyannikov AG; Research Institute of Medical Primatology, Sochi, Russia., Araviashvili DE; Research Institute of Medical Primatology, Sochi, Russia., Klots IN; Research Institute of Medical Primatology, Sochi, Russia., Lapin BA; Research Institute of Medical Primatology, Sochi, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2018 May; Vol. 165 (1), pp. 101-104. Date of Electronic Publication: 2018 May 24.
DOI: 10.1007/s10517-018-4108-8
Abstrakt: Three injections of doxorubicin to rhesus macaques cause severe intoxication, characterized by anemia, cachexia, and degeneration of the viscera. The life span of monkeys injected with the drug and receiving after 24 h mesenchymal stem cell transplantation varied from 96 to 120 days in comparison with 50-74 days in animals receiving stem cells before doxorubicin. Controls received doxorubicin and saline; the lifespan of one monkey was 24 days, of the other - 1 year and 8 months. The increase in activity of proinflammatory cytokine IL-6 was paralleled by an increase in the level of C-reactive protein.
Databáze: MEDLINE
Externí odkaz: