Ancestry-specific recent effective population size in the Americas.

Autor: Browning SR; Department of Biostatistics, University of Washington, Seattle, WA, United States of America., Browning BL; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, United States of America., Daviglus ML; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, United States of America., Durazo-Arvizu RA; Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Chicago, IL, United States of America., Schneiderman N; Department of Psychology, University of Miami, Coral Gables, FL, United States of America., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States of America., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, United States of America.
Jazyk: angličtina
Zdroj: PLoS genetics [PLoS Genet] 2018 May 24; Vol. 14 (5), pp. e1007385. Date of Electronic Publication: 2018 May 24 (Print Publication: 2018).
DOI: 10.1371/journal.pgen.1007385
Abstrakt: Populations change in size over time due to factors such as population growth, migration, bottleneck events, natural disasters, and disease. The historical effective size of a population affects the power and resolution of genetic association studies. For admixed populations, it is not only the overall effective population size that is of interest, but also the effective sizes of the component ancestral populations. We use identity by descent and local ancestry inferred from genome-wide genetic data to estimate overall and ancestry-specific effective population size during the past hundred generations for nine admixed American populations from the Hispanic Community Health Study/Study of Latinos, and for African-American and European-American populations from two US cities. In these populations, the estimated pre-admixture effective sizes of the ancestral populations vary by sampled population, suggesting that the ancestors of different sampled populations were drawn from different sub-populations. In addition, we estimate that overall effective population sizes dropped substantially in the generations immediately after the commencement of European and African immigration, reaching a minimum around 12 generations ago, but rebounded within a small number of generations afterwards. Of the populations that we considered, the population of individuals originating from Puerto Rico has the smallest bottleneck size of one thousand, while the Pittsburgh African-American population has the largest bottleneck size of two hundred thousand.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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