Synergistic Phytochemicals Fail to Protect Against Ovariectomy Induced Bone Loss in Rats.

Autor:	Ambati S; 1 Department of Animal and Dairy Sciences, University of Georgia , Athens, Georgia , USA., Miller CN; 1 Department of Animal and Dairy Sciences, University of Georgia , Athens, Georgia , USA.; 2 Department of Foods and Nutrition, University of Georgia , Athens, Georgia , USA., Bass EF; 1 Department of Animal and Dairy Sciences, University of Georgia , Athens, Georgia , USA., Hohos NM; 2 Department of Foods and Nutrition, University of Georgia , Athens, Georgia , USA., Hartzell DL; 1 Department of Animal and Dairy Sciences, University of Georgia , Athens, Georgia , USA., Kelso EW; 1 Department of Animal and Dairy Sciences, University of Georgia , Athens, Georgia , USA., Trunnell ER; 3 Neuroscience Division, Biomedical and Health Sciences Institute, University of Georgia , Athens, Georgia , USA., Yang JY; 2 Department of Foods and Nutrition, University of Georgia , Athens, Georgia , USA., Della-Fera MA; 1 Department of Animal and Dairy Sciences, University of Georgia , Athens, Georgia , USA., Baile CA; 1 Department of Animal and Dairy Sciences, University of Georgia , Athens, Georgia , USA.; 2 Department of Foods and Nutrition, University of Georgia , Athens, Georgia , USA., Rayalam S; 4 Department of Pharmaceutical Sciences, GA Campus-Philadelphia College of Osteopathic Medicine , Suwanee, Georgia , USA.
Jazyk:	angličtina
Zdroj:	Journal of medicinal food [J Med Food] 2018 Oct; Vol. 21 (10), pp. 1044-1052. Date of Electronic Publication: 2018 May 24.
DOI:	10.1089/jmf.2017.0113
Abstrakt:	Menopause induces a loss of bone as a result of estrogen deficiency. Despite pharmaceutical options for the treatment of osteopenia and osteoporosis, many aging women use dietary supplements with estrogenic activity to prevent bone loss and other menopausal-related symptoms. Such supplements are yet to be tested for efficacy against a Food and Drug Administration (FDA) approved medication for menopausal bone loss such as zoledronic acid (ZA). The postmenopausal rat model was used to investigate the efficacy of various synergistic phytochemical blends mixed into the diet for 16 weeks. Retired-breeder, Fischer 344 rats were randomly assigned to sham or ovariectomy surgery and 4 treatment groups: ZA; genistein supplementation; and a low dose and high dose blend of genistein, resveratrol, and quercetin. Ovariectomy resulted in a loss of both trabecular and cortical bone which was prevented with ZA. The phytochemical blends tested were unable to reverse these losses. Despite the lack of effectiveness in preventing bone loss, a significant dose-response trend was observed in the phytochemical-rich diets in bone adipocyte number compared to ovariectomized control rats. Data from this study indicate that estrogenic phytochemicals are not as efficacious as ZA in preventing menopausal-related bone loss but may have beneficial effects on bone marrow adiposity in rats.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu