Melanopsin Retinal Ganglion Cells Regulate Cone Photoreceptor Lamination in the Mouse Retina.

Autor:	Tufford AR; Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada; Integrated Program in Neuroscience, McGill University, Montréal, QC, Canada., Onyak JR; Department of Biology, University of Akron, Akron, OH, USA., Sondereker KB; Department of Biology, University of Akron, Akron, OH, USA., Lucas JA; Department of Neurobiology, Northwestern University, Evanston, IL, USA., Earley AM; Department of Neurobiology, Northwestern University, Evanston, IL, USA., Mattar P; Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada., Hattar S; National Institute of Mental Health, Bethesda, MD, USA., Schmidt TM; Department of Neurobiology, Northwestern University, Evanston, IL, USA., Renna JM; Department of Biology, University of Akron, Akron, OH, USA., Cayouette M; Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada; Integrated Program in Neuroscience, McGill University, Montréal, QC, Canada; Department of Medicine, Université de Montréal, Montréal, QC, Canada; Department of Anatomy and Cell Biology and Division of Experimental Medicine, McGill University, Montréal, QC, Canada. Electronic address: michel.cayouette@ircm.qc.ca.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2018 May 22; Vol. 23 (8), pp. 2416-2428.
DOI:	10.1016/j.celrep.2018.04.086
Abstrakt:	Newborn neurons follow molecular cues to reach their final destination, but whether early life experience influences lamination remains largely unexplored. As light is among the first stimuli to reach the developing nervous system via intrinsically photosensitive retinal ganglion cells (ipRGCs), we asked whether ipRGCs could affect lamination in the developing mouse retina. We show here that ablation of ipRGCs causes cone photoreceptors to mislocalize at different apicobasal positions in the retina. This effect is partly mediated by light-evoked activity in ipRGCs, as dark rearing or silencing of ipRGCs leads a subset of cones to mislocalize. Furthermore, ablation of ipRGCs alters the cone transcriptome and decreases expression of the dopamine receptor D4, while injection of L-DOPA or D4 receptor agonist rescues the displaced cone phenotype observed in dark-reared animals. These results show that early light-mediated activity in ipRGCs influences neuronal lamination and identify ipRGC-elicited dopamine release as a mechanism influencing cone position. (Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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