The Low-Threshold Calcium Channel Cav3.2 Mediates Burst Firing of Mature Dentate Granule Cells.

Autor:	Dumenieu M; Research Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestr. 6, Magdeburg, Germany., Senkov O; Molecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany., Mironov A; Molecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod, Russia.; Privolzhsky Research Medical University, Nizhny Novgorod, Russia., Bourinet E; Calcium Channel Dynamics & Nociception Group, Institute of Functional Genomics, Montpellier, France., Kreutz MR; Research Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestr. 6, Magdeburg, Germany.; Leibniz Group 'Dendritic Organelles and Synaptic Function,' University Medical Center Hamburg-Eppendorf, Center for Molecular Neurobiology (ZMNH), Hamburg, Germany., Dityatev A; Molecular Neuroplasticity Group, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.; Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.; Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany., Heine M; Research Group Molecular Physiology, Leibniz Institute for Neurobiology, Brenneckestr. 6, Magdeburg, Germany., Bikbaev A; Research Group Molecular Physiology, Leibniz Institute for Neurobiology, Brenneckestr. 6, Magdeburg, Germany., Lopez-Rojas J; Research Group Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestr. 6, Magdeburg, Germany.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2018 Jul 01; Vol. 28 (7), pp. 2594-2609.
DOI:	10.1093/cercor/bhy084
Abstrakt:	Mature granule cells are poorly excitable neurons that were recently shown to fire action potentials, preferentially in bursts. It is believed that the particularly pronounced short-term facilitation of mossy fiber synapses makes granule cell bursting a very effective means of properly transferring information to CA3. However, the mechanism underlying the unique bursting behavior of mature granule cells is currently unknown. Here, we show that Cav3.2 T-type channels at the axon initial segment are responsible for burst firing of mature granule cells in rats and mice. Accordingly, Cav3.2 knockout mice fire tonic spikes and exhibit impaired bursting, synaptic plasticity and dentate-to-CA3 communication. The data show that Cav3.2 channels are strong modulators of bursting and can be considered a critical molecular switch that enables effective information transfer from mature granule cells to the CA3 pyramids.
Databáze:	MEDLINE
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