Biochemical markers of hypertension, prehypertension.
Autor: | Turgunova L; Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan. Electronic address: turgunova@kgmu.kz., Koichubekov B; Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan. Electronic address: koychubekov@kgmu.kz., Turmuhambetova A; Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan. Electronic address: turmuhambetova@kgmu.kz., Sorokina M; Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan. Electronic address: M.Sorokina@kgmu.kz., Laryushina YE; Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan. Electronic address: laryushina@kgmu.kz., Korshukov I; Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan. Electronic address: korshukov@kgmu.kz., Shalygina A; Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan. Electronic address: shalygina@kgmu.kz., Baidildina B; Karaganda State Medical University, 40, Gogol Street, 100008 Karaganda, Kazakhstan. Electronic address: baidildina@kgmu.kz. |
---|---|
Jazyk: | angličtina |
Zdroj: | Annales de cardiologie et d'angeiologie [Ann Cardiol Angeiol (Paris)] 2018 Jun; Vol. 67 (3), pp. 161-166. Date of Electronic Publication: 2018 May 19. |
DOI: | 10.1016/j.ancard.2018.04.023 |
Abstrakt: | Objective: There are insufficient researches aimed at evaluating biochemical markers of mechanisms of formation of AH and lesion of target organs in hypertension and prehypertension. The aim of that research was to study the level of endothelial dysfunction markers and damage to the cardiovascular system in hypertension and prehypertension. Patients and Methods: A cross-sectional study was performed among 938 people aged 18 to 65 years. All respondents were surveyed, blood pressure measured, for glucose, cholesterol, interleukin-6, sFAS, LIGHT, hFABP, NT-ProBNP and an Endocan concentrations were tested. Depending on the level of blood pressure participants were splitted into groups with normotension, prehypertension and hypertension. Results: Comparing the markers of inflammation, apoptosis and target organ damage in the prehypertensive group, the level of the LIGHT protein was Me=265.2pg/ml (Q Conclusion: Thus, the development of prehypertension and hypertension is characterized by an increase in the activity of biochemical markers of endothelial dysfunction and damage to target organs, more expressed in the presence of hypertension. (Copyright © 2018 Elsevier Masson SAS. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |