| Autor: |
Ying ZT; Department of Lymphoma, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China., Mi L, Wang XJ, Zhang YW, Yang Z, Song YQ, Wang XP, Zheng W, Lin NJ, Tu MF, Xie Y, Ping LY, Zhang C, Liu WP, Deng LJ, Zhu J |
| Jazyk: |
čínština |
| Zdroj: |
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2018 May 14; Vol. 39 (5), pp. 382-386. |
| DOI: |
10.3760/cma.j.issn.0253-2727.2018.05.007 |
| Abstrakt: |
Objective: To evaluate the prognostic value of (18)F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) in patients with diffuse large B cell lymphoma (DLBCL) undergoing autologous hematopoietic stem cell transplantation (auto-HSCT). Methods: Forty-eight patients with DLBCL treated at Peking University Cancer Hospital between November 2010 and December 2014 were assessed. All patients underwent PET/CT scanning prior to or after auto-HSCT. Correlation analysis was done based upon patients characteristics, PET/CT scan results and survival. Results: ①Among 48 patients, 27 was male, 21 female, median age was 43 (17-59) years old. ② Patients with negative pre-auto-HSCT PET/CT assessment demonstrated significantly better 3-year progression free survival (PFS) (87.1% vs 53.3%, χ (2)=7.02, P =0.019) and overall survival (OS) (90.3% vs 60.0%, χ (2)=6.51, P =0.022) than patients with positive pre-auto-HSCT PET/CT assessment. Three-year PFS (94.1% vs 30.0%, χ (2)=22.75, P =0.001) and OS (97.1% vs 40.0%, χ (2)=21.09, P =0.002) were also significantly different between patients with negative and positive post-auto-HSCT PET/CT assessment. ③ Multivariate analysis indicated a significant association of PFS ( HR =13.176, P =0.005) and OS ( HR =20.221, P =0.007) with post-auto-HSCT PET/CT assessment. Number of prior treatment regimens was associated with PFS ( HR =10.039, P =0.040). ④ Harrell's C index revealed that the value of combined use of number of prior treatment regimens and post-auto-HSCT PET/CT assessment was superior to either one used alone in PFS (Harrell's C values were 0.976, 0.869 and 0.927 in combined use, number of prior treatment regimens and post-auto-HSCT PET/CT assessment, respectively), and the combined use of ECOG performance status and post-auto-HSCT PET/CT assessment significantly increased the Harrell's C index in OS (Harrell's C values were 0.973, 0.711 and 0.919 in combined use, ECOG performance status and post-auto-HSCT PET/CT assessment, respectively). Conclusions: Post-auto-HSCT PET/CT assessment is the main predictor of outcomes in DLBCL patients receiving auto-HSCT. Combined use of post-auto-HSCT PET/CT assessment and number of prior treatment regimens and ECOG performance status is a better prognostic tool in patients with DLBCL undergoing transplantation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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